Publication Name	World Journal of Stem Cells
Manuscript ID	16743
Country	Ecuador

Received	2015-01-28 22:00
Peer-Review Started	2015-01-31 09:56
To Make the First Decision	2015-02-07 14:53
Return for Revision	2015-02-10 15:02
Revised	2015-03-13 04:05
Second Decision	2015-04-01 15:34
Accepted by Journal Editor-in-Chief	2015-04-03 08:34
Accepted by Executive Editor-in-Chief	2015-04-14 16:27
Articles in Press	2015-04-14 16:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-05-15 14:29
Publish the Manuscript Online	2015-05-31 19:16

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cell Biology
Manuscript Type	Editorial
Article Title	Spermatogonial stem cells: Current biotechnological advances in reproduction and regenerative medicine
Manuscript Source	Invited Manuscript
All Author List	Pedro Manuel Aponte
Funding Agency and Grant Number
Corresponding Author	Pedro Manuel Aponte, DVM, PhD, Scientific Adviser at AGROCALIDAD/Project Prometeo - SENESCYT, Av. 9 de Octubre N22-48 y Jerónimo Carrión, Casa Patrimonial, Quito 170184, Ecuador. apontep@gmail.com
Key Words	Cell culture; Spermatogonial stem cells; Spermatogenesis; Pluripotency; Transplantation; Fertility
Core Tip	This article reviews the current body of knowledge on biotechnological applications of sperma-togonial stem cells (SSCs). SSCs are the founding adult germ stem cells of the sperm producing process spermatogenesis. SSCs belong to the male germline and can be expanded in vitro in several species. Through mechanisms not fully understood they can derive pluripotent stem cells in vitro. Thus, they can be genetically modified with some advantages over embryonic stem cell-based technologies. SSCs can be transplanted to homotopical or ectopical locations, offering great potentials in fertility related issues and regenerative clinical applications in domestic or wild animals and men.
Publish Date	2015-05-31 19:16
Citation	Aponte PM. Spermatogonial stem cells: Current biotechnological advances in reproduction and regenerative medicine. World J Stem Cells 2015; 7(4): 669-680
URL	http://www.wjgnet.com/1948-0210/full/v7/i4/669.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i4.669

Full Article (PDF)	WJSC-7-669.pdf
Full Article (Word)	WJSC-7-669.doc
Manuscript File	16743-Review.docx
Answering Reviewers	16743-Answering reviewers.pdf
Audio Core Tip	16743-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16743-Conflict-of-interest statement.pdf
Copyright License Agreement	16743-Copyright assignment.pdf
Peer-review Report	16743-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16743-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16743-Scientific misconduct check.pdf
Scientific Editor Work List	16743-Scientific editor work list.pdf