Publication Name	World Journal of Gastroenterology
Manuscript ID	16751
Country	Taiwan

Received	2015-01-29 09:59
Peer-Review Started	2015-01-29 21:59
To Make the First Decision	2015-04-13 15:52
Return for Revision	2015-04-14 10:33
Revised	2015-04-27 13:43
Second Decision	2015-09-28 16:02
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-30 09:58
Articles in Press	2015-09-30 09:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-20 10:29
Publish the Manuscript Online	2015-11-11 13:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Hepatic immune tolerance induced by hepatic stellate cells
Manuscript Source	Invited Manuscript
All Author List	Ching-Chuan Hsieh, Chien-Hui Hung, Lina Lu and Shiguang Qian
Funding Agency and Grant Number	Funding Agency Grant Number National Science Council NSC 101-2314-B-182A-040-MY2 National Science Council CMRPG6A0523
Corresponding Author	Ching-Chuan Hsieh, MD, Department of Surgery, Chang Gung Memorial Hospital at Chiayi, 6 Sec. West Chia-Pu Road, Pu-Zi City, Chiayi 613, Taiwan. jeffrey570404@gmail.com
Key Words	Hepatic stellate cells; Myeloid-derived suppressor cells; Hepatic tolerance; Immunotherapy
Core Tip	The liver is an immune privileged organ that contains cells exhibiting powerful immune regulatory activity. Hepatic stellate cells (HpSCs) possess weak antigen-presenting ability and function as immunological bystander cells in the regulation of the immune response by the way of induction of effector T cell apoptosis and the generation of myeloid-derived suppressor cells and regulatory T cells. The combination of these mechanisms indicates that HpSCs are a potent immunoregulatory entity capable of modulating immune responses in the liver. HpSCs can orchestrate both innate immunity and adaptive immunity to build a negative immune network that leads to immune tolerance. Further understanding of hepatic immune tolerance will provide the basis for developing new immunotherapies that target transplant rejection, chronic viral infection and cancer.
Publish Date	2015-11-11 13:34
Citation	Hsieh CC, Hung CH, Lu L, Qian S. Hepatic immune tolerance induced by hepatic stellate cells. World J Gastroenterol 2015; 21(42): 11887-11892
URL	http://www.wjgnet.com/1007-9327/full/v21/i42/11887.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i42.11887

Full Article (PDF)	WJG-21-11887.pdf
Full Article (Word)	WJG-21-11887.doc
Manuscript File	16751-Review.docx
Answering Reviewers	16751-Answering reviewers.pdf
Audio Core Tip	16751-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16751-Conflict-of-interest statement.pdf
Copyright License Agreement	16751-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	16751-Language certificate.pdf
Peer-review Report	16751-Peer-review(s).pdf
Scientific Misconduct Check	16751-Scientific misconduct check.pdf
Scientific Editor Work List	16751-Scientific editor work list.pdf