Publication Name	World Journal of Methodology
Manuscript ID	16777
Country	Italy

Received	2015-01-29 09:10
Peer-Review Started	2015-01-29 16:50
To Make the First Decision	2015-03-20 11:46
Return for Revision	2015-03-27 13:59
Revised	2015-04-01 18:10
Second Decision	2015-05-08 17:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-05-18 17:23
Articles in Press	2015-05-18 17:23
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-11 16:39
Publish the Manuscript Online	2015-07-07 20:52

ISSN	2222-0682 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Urology & Nephrology
Manuscript Type	Editorial
Article Title	Costimulatory blockade: A novel approach to the treatment of glomerular disease?
Manuscript Source	Invited Manuscript
All Author List	Pasquale Esposito, Teresa Rampino and Antonio Dal Canton
Funding Agency and Grant Number
Corresponding Author	Pasquale Esposito, MD, PhD, Department of Nephrology, Dialysis and Transplantation, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Piazzale Golgi 19, 27100 Pavia, Italy. pasqualeesposito@hotmail.com
Key Words	Costimulation; Glomerulonephritis; Cluster of differentiation 80; Cytotoxic T-lymphocyte-associated antigen-4; Lupus nephritis; Abatacept; Proteinuria; Podocytes
Core Tip	Glomerulonephritis refer to a group of renal disorders, primary or secondary to infections, drugs or systemic diseases, characterized by inflammation within the glomerulus. Among glomerular diseases there is a great clinical, histological and prognostic heterogeneity and several different pathogenetic mechanisms have been implied. Current standard treatments include steroids and cytotoxic agents, which present important side effects and an unsatisfactory remission rate. Therefore, experimental and clinical research is addressed to the development of alternative therapies. Here, we critically discuss new therapeutic opportunities provided by the use of agents acting on the modulation of costimulatory pathways.
Publish Date	2015-07-07 20:52
Citation	Esposito P, Rampino T, Dal Canton A. Costimulatory blockade: A novel approach to the treatment of glomerular disease? World J Methodol 2015; 5(2): 20-25
URL	http://www.wjgnet.com/2222-0682/full/v5/i2/20.htm
DOI	http://dx.doi.org/10.5662/wjm.v5.i2.20

Full Article (PDF)	WJM-5-20.pdf
Full Article (Word)	WJM-5-20.doc
Manuscript File	16777-Review.doc
Answering Reviewers	16777-Answering reviewers.pdf
Audio Core Tip	16777-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16777-Conflict-of-interest statement.pdf
Copyright License Agreement	16777-Copyright assignment.pdf
Peer-review Report	16777-Peer-review(s).pdf
Scientific Misconduct Check	16777-Scientific misconduct check.pdf
Scientific Editor Work List	16777-Scientific editor work list.pdf