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9/16/2014 1:19:00 PM | Browse: 422 | Download: 308
Publication Name World Journal of Gastroenterology
Manuscript ID 1681
Country/Territory China
Received
2012-12-27 15:15
Peer-Review Started
2012-12-28 11:21
To Make the First Decision
2013-01-05 11:30
Return for Revision
2013-01-06 08:29
Revised
2013-01-13 12:19
Second Decision
2013-02-08 09:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-02-08 11:39
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-03-30 20:49
Publish the Manuscript Online
2013-04-14 19:05
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Surgery
Manuscript Type Autobiography
Article Title miRNA-338-3p suppresses cell growth of human colorectal carcinoma by targeting smoothened
Manuscript Source Invited Manuscript
All Author List Kai Sun, Hai-Jun Deng, Shang-Tong Lei, Jing-Qing Dong and Guo-Xin Li
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81101896
Corresponding author Dr. Kai Sun, Department of General Surgery, Nanfang Hospital of Southern Medical University, Guangzhou Dadao North Street No. 1838, Guangzhou 510515, Guangdong Province, China. sunkai9602@sina.com
Keywords Colorectal carcinoma; Hsa-miRNA-338-3p; Smoothened; Lentivirus
Core Tip The previous study has shown that loss of miR-338-3p expression is associated with clinical aggressiveness of colorectal carcinoma (CRC). In this study, the authors demonstrated that forced expression of miR-338-3p in CRC cells suppressed cell proliferation and induced apoptosis, whereas inhibition of miR-338-3p in CRC cells promoted growth. We described miR-338-3p as a direct regulator of smoothened (SMO) expression in CRC, showing a new mechanism responsible for SMO upregulation in CRC. This study provides evidence for antiangiogenic activity of miR-338-3p in the development of CRC and it may develop as a useful biomarker or therapeutic target in CRC.
Publish Date 2013-04-14 19:05
Citation Sun K, Deng HJ, Lei ST, Dong JQ, Li GX. miRNA-338-3p suppresses cell growth of human colorectal carcinoma by targeting smoothened. World J Gastroenterol 2013; 19(14): 2197-2207
Url http://www.wjgnet.com/1007-9327/full/v19/i14/2197.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i14.2197
Full Article (PDF) WJG-19-2197.pdf
Manuscript File 1681-Review.doc
Answering Reviewers 1681-Answering reviewers.doc
Copyright License Agreement 1681-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate 1681-Language certificate.doc
Peer-review Report 1681-Peer review(s).docx
Scientific Editor Work List 1681-Scientific editor work list.doc