Publication Name	World Journal of Gastroenterology
Manuscript ID	1681
Country	China

Received	2012-12-27 15:15
Peer-Review Started	2012-12-28 11:21
To Make the First Decision	2013-01-05 11:30
Return for Revision	2013-01-06 08:29
Revised	2013-01-13 12:19
Second Decision	2013-02-08 09:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-02-08 11:39
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-03-30 20:49
Publish the Manuscript Online	2013-04-14 19:05

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Surgery
Manuscript Type	Autobiography
Article Title	miRNA-338-3p suppresses cell growth of human colorectal carcinoma by targeting smoothened
Manuscript Source	Invited Manuscript
All Author List	Kai Sun, Hai-Jun Deng, Shang-Tong Lei, Jing-Qing Dong and Guo-Xin Li
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81101896
Corresponding Author	Dr. Kai Sun, Department of General Surgery, Nanfang Hospital of Southern Medical University, Guangzhou Dadao North Street No. 1838, Guangzhou 510515, Guangdong Province, China. sunkai9602@sina.com
Key Words	Colorectal carcinoma; Hsa-miRNA-338-3p; Smoothened; Lentivirus
Core Tip	The previous study has shown that loss of miR-338-3p expression is associated with clinical aggressiveness of colorectal carcinoma (CRC). In this study, the authors demonstrated that forced expression of miR-338-3p in CRC cells suppressed cell proliferation and induced apoptosis, whereas inhibition of miR-338-3p in CRC cells promoted growth. We described miR-338-3p as a direct regulator of smoothened (SMO) expression in CRC, showing a new mechanism responsible for SMO upregulation in CRC. This study provides evidence for antiangiogenic activity of miR-338-3p in the development of CRC and it may develop as a useful biomarker or therapeutic target in CRC.
Publish Date	2013-04-14 19:05
Citation	Sun K, Deng HJ, Lei ST, Dong JQ, Li GX. miRNA-338-3p suppresses cell growth of human colorectal carcinoma by targeting smoothened. World J Gastroenterol 2013; 19(14): 2197-2207
URL	http://www.wjgnet.com/1007-9327/full/v19/i14/2197.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i14.2197

Full Article (PDF)	WJG-19-2197.pdf
Manuscript File	1681-Review.doc
Answering Reviewers	1681-Answering reviewers.doc
Copyright License Agreement	1681-Copyright assignment.doc
Non-Native Speakers of English Editing Certificate	1681-Language certificate.doc
Peer-review Report	1681-Peer review(s).docx
Scientific Editor Work List	1681-Scientific editor work list.doc