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8/28/2015 5:05:00 PM | Browse: 484 | Download: 994
Publication Name World Journal of Gastroenterology
Manuscript ID 16811
Country of Manuscript Source China
Received
2015-01-29 21:15
Peer-Review Started
2015-01-30 21:30
To Make the First Decision
2015-03-10 17:42
Return for Revision
2015-03-16 09:00
Revised
2015-04-16 01:25
Second Decision
2015-05-29 14:05
Accepted by Journal Editor-in-Chief
2015-05-29 19:32
Accepted by Company Editor-in-Chief
2015-06-10 16:08
Articles in Press
2015-06-10 16:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-07-21 21:12
Typeset the Manuscript
2015-08-13 17:48
Publish the Manuscript Online
2015-08-28 17:04
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Histological outcome for chronic hepatitis B patients treated with entecavir vs lamivudine-based therapy
Manuscript Source Unsolicited Manuscript
All Author List Jia-Li Wang, Xin-Fang Du, Shao-Long Chen, Yi-Qi Yu, Jing Wang, Xi-Qi Hu, Ling-Yun Shao, Jia-Zhen Chen, Xin-Hua Weng and Wen-Hong Zhang
Funding Agency and Grant Number
Funding Agency Grant Number
Key Medical Specialties Fund of Shanghai Municipal Health Bureau 05II011 2-1
Corresponding author Wen-Hong Zhang, Professor, Department of Infectious Diseases, Huashan Hospital, 12 Wulumuqi Zhong Road, Shanghai 200040, China. zhangwenhong@fudan.edu.cn
Keywords Advanced fibrosis; Chronic hepatitis B; Cirrhosis; Entecavir; Histological outcome; Lamivudine
Core Tip This retrospective cohort study compared the histological outcomes of long-term antiviral treatment for an average of more than 3 years with entecavir monotherapy or lamivudine-based combination therapy in chronic hepatitis B patients with significant fibrosis or cirrhosis. There was a histological improvement observed in the majority of patients in both arms. There were also improved virological responses, alanine aminotransferase normalization, and serological responses. Additionally, 4 of 48 patients achieved a full reversion of fibrosis or cirrhosis. Entecavir was superior to lamivudine-based therapy in improving necroinflammatory but not fibrotic outcome.
Publish Date 2015-08-28 17:04
Citation Wang JL, Du XF, Chen SL, Yu YQ, Wang J, Hu XQ, Shao LY, Chen JZ, Weng XH, Zhang WH. Histological outcome for chronic hepatitis B patients treated with entecavir vs lamivudine-based therapy. World J Gastroenterol 2015; 21(32): 9598-9606
Url http://www.wjgnet.com/1007-9327/full/v21/i32/9598.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i32.9598
Full Article (PDF) WJG-21-9598.pdf
Full Article (Word) WJG-21-9598.doc
Manuscript File 16811-Review.doc
Answering Reviewers 16811-Answering reviewers.pdf
Audio Core Tip 16811-Audio core tip.wma
Biostatistics Review Certificate 16811-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 16811-Conflict-of-interest statement.pdf
Copyright License Agreement 16811-Copyright assignment.pdf
Data Sharing Statement 16811-Data sharing statement.pdf
Institutional Review Board Approval Form or Document 16811-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 16811-Language certificate.pdf
Peer-review Report 16811-Peer reviews.pdf
Journal Editor-in-Chief Review Report 16811-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 16811-Scientific misconduct check.pdf
Scientific Editor Work List 16811-Scientific editor work list.pdf