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Articles Published Processes
8/28/2015 5:05:00 PM | Browse: 1207 | Download: 2593
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Received |
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2015-01-29 21:15 |
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Peer-Review Started |
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2015-01-30 21:30 |
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To Make the First Decision |
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2015-03-10 17:42 |
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Return for Revision |
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2015-03-16 09:00 |
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Revised |
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2015-04-16 01:25 |
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Second Decision |
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2015-05-29 14:05 |
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Accepted by Journal Editor-in-Chief |
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2015-05-29 19:32 |
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Accepted by Executive Editor-in-Chief |
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2015-06-10 16:08 |
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Articles in Press |
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2015-06-10 16:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-07-21 21:12 |
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Typeset the Manuscript |
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2015-08-13 17:48 |
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Publish the Manuscript Online |
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2015-08-28 17:04 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Histological outcome for chronic hepatitis B patients treated with entecavir vs lamivudine-based therapy
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jia-Li Wang, Xin-Fang Du, Shao-Long Chen, Yi-Qi Yu, Jing Wang, Xi-Qi Hu, Ling-Yun Shao, Jia-Zhen Chen, Xin-Hua Weng and Wen-Hong Zhang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Key Medical Specialties Fund of Shanghai Municipal Health Bureau |
05II011 2-1 |
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| Corresponding Author |
Wen-Hong Zhang, Professor, Department of Infectious Diseases, Huashan Hospital, 12 Wulumuqi Zhong Road, Shanghai 200040, China. zhangwenhong@fudan.edu.cn |
| Key Words |
Advanced fibrosis; Chronic hepatitis B; Cirrhosis; Entecavir; Histological outcome; Lamivudine |
| Core Tip |
This retrospective cohort study compared the histological outcomes of long-term antiviral treatment for an average of more than 3 years with entecavir monotherapy or lamivudine-based combination therapy in chronic hepatitis B patients with significant fibrosis or cirrhosis. There was a histological improvement observed in the majority of patients in both arms. There were also improved virological responses, alanine aminotransferase normalization, and serological responses. Additionally, 4 of 48 patients achieved a full reversion of fibrosis or cirrhosis. Entecavir was superior to lamivudine-based therapy in improving necroinflammatory but not fibrotic outcome. |
| Publish Date |
2015-08-28 17:04 |
| Citation |
Wang JL, Du XF, Chen SL, Yu YQ, Wang J, Hu XQ, Shao LY, Chen JZ, Weng XH, Zhang WH. Histological outcome for chronic hepatitis B patients treated with entecavir vs lamivudine-based therapy. World J Gastroenterol 2015; 21(32): 9598-9606 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i32/9598.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i32.9598 |
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