Publication Name	World Journal of Hepatology
Manuscript ID	16820
Country	Italy

Received	2015-01-29 15:45
Peer-Review Started	2015-02-02 09:17
To Make the First Decision	2015-03-06 10:27
Return for Revision	2015-03-11 19:47
Revised	2015-03-30 00:00
Second Decision	2015-04-22 17:14
Accepted by Journal Editor-in-Chief	2015-04-22 18:51
Accepted by Company Editor-in-Chief	2015-05-06 15:39
Articles in Press	2015-05-06 15:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-30 09:51
Publish the Manuscript Online	2015-07-24 19:52

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Allergy
Manuscript Type	Editorial
Article Title	Spontaneous bleeding or thrombosis in cirrhosis: What should be feared the most?
Manuscript Source	Invited Manuscript
All Author List	Kryssia Isabel Rodríguez-Castro, Alessandro Antonello and Alberto Ferrarese
Funding Agency and Grant Number
Corresponding Author	Dr. Kryssia Isabel Rodríguez-Castro, MD, PhD, Department of Surgery, Oncology and Gastroen­terology, Padua University Hospital, Via Giustiniani 2, 35128 Padua, Italy. kryssiarodriguez@yahoo.com
Key Words	Bleeding; Hemorrhage; Thromboembolism; Portal vein thrombosis; Coagulation; Cirrhosis
Core Tip	The two-faced, dynamic, and fragile hemostatic and coagulation system of patients with cirrhosis is of increasing interest. Thrombotic complications, and not only the well-known bleeding complications such as gastroesophageal bleeding, are now recognized complications of cirrhosis. Whether confined to the portal vein, due to venous stasis but also to other yet poorly characterized local as well as systemic factors, or in the presence venous thromboembolism, these complications warrant prevention and treatment with anticoagulation. Future clinical studies, as well as the broader implementation of point-of-care instruments and results from studies using global coagulation assays will outline the best strategies, tailored to each patient according to the severity of liver disease and the particular hemostatic alterations present at a given timepoint.
Publish Date	2015-07-24 19:52
Citation	Rodríguez-Castro KI, Antonello A, Ferrarese A. Spontaneous bleeding or thrombosis in cirrhosis: What should be feared the most? World J Hepatol 2015; 7(14): 1818-1827
URL	http://www.wjgnet.com/1948-5182/full/v7/i14/1818.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i14.1818

Full Article (PDF)	WJH-7-1818.pdf
Full Article (Word)	WJH-7-1818.doc
Manuscript File	16820-Review.docx
Answering Reviewers	16820-Answering reviewers.pdf
Audio Core Tip	16820-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16820-Conflict-of-interest statement.pdf
Copyright License Agreement	16820-Copyright assignment.pdf
Peer-review Report	16820-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16820-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16820-Scientific misconduct check.pdf
Scientific Editor Work List	16820-Scientific editor work list.pdf