Publication Name	World Journal of Gastroenterology
Manuscript ID	16835
Country	China

Received	2015-01-30 08:27
Peer-Review Started	2015-01-30 15:34
To Make the First Decision	2015-03-10 17:39
Return for Revision	2015-03-16 09:04
Revised	2015-03-26 19:20
Second Decision	2015-04-23 08:25
Accepted by Journal Editor-in-Chief	2015-04-23 16:03
Accepted by Executive Editor-in-Chief	2015-05-04 18:10
Articles in Press	2015-05-04 18:10
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-05-17 23:19
Typeset the Manuscript	2015-07-06 18:25
Publish the Manuscript Online	2015-07-30 11:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Hepatitis B surface antigen levels of cessation of nucleos(t)ide analogs associated with virological relapse in hepatitis B surface antigen-negative chronic hepatitis B patients
Manuscript Source	Unsolicited Manuscript
All Author List	Guo-Hong Ge, Yun Ye, Xin-Bei Zhou, Li Chen, Cong He, Dan-Feng Wen and You-Wen Tan
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of Jiangsu Province, China BK2011515 Medical Project of Health Department Jiangsu Province H201248 Preventive Medicine research projects of Jiangsu Province Y2012016 Social Development Project of Zhenjiang City SH2013056
Corresponding Author	Yun Ye, Associate Professor, Department of Hepatosis, The Third Hospital of Zhenjiang Affiliated Jiangsu University, No. 300 Daijiamen, Runzhou Distinct, Zhenjiang 212000, Jiangsu Province, China. tyw915@sina.com
Key Words	Chronic hepatitis B; Virological relapse; Hepatitis B surface antigen
Core Tip	To study the rate of virological relapse in hepatitis B e antigen (HBeAg)-negative patients after stopping antiviral therapy. Two hundred and four patients were eligible for this analysis. The cumulative probability of virological relapse after stopping antiviral therapy was 79.41% (162/204) in 2 years and 43.82% (71/162) in 1 year. Cumulative probability of virological relapse in levels of the hepatitis B surface antigen (HBsAg) ≥ 1500IU/L group was higher than that of levels of the HBsAg < 1500 IU/L group. The cutoff value for predicting virological relapse was 1443 IU/L. We found that the virological relapse rate maintained a high level after stopping NUCs in HBeAg-negative patients and HBsAg levels of cessation of nucleos(t)ide analogs predicted virological relapse.
Publish Date	2015-07-30 11:17
Citation	Ge GH, Ye Y, Zhou XB, Chen L, He C, Wen DF, Tan YW. Hepatitis B surface antigen levels of cessation of nucleos(t)ide analogs associated with virological relapse in hepatitis B surface antigen-negative chronic hepatitis B patients. World J Gastroenterol 2015; 21(28): 8653-8659
URL	http://www.wjgnet.com/1007-9327/full/v21/i28/8653.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i28.8653

Full Article (PDF)	WJG-21-8653.pdf
Full Article (Word)	WJG-21-8653.doc
Manuscript File	16835-Review.docx
Answering Reviewers	16835-Answering Reviewers.pdf
Audio Core Tip	16835-Audio core tip.mp3
Biostatistics Review Certificate	16835-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	16835-Conflict of interest statement.pdf
Copyright License Agreement	16835-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	16835-Institutional Review Board statement.pdf
Peer-review Report	16835-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16835-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16835-Scientific misconduct check.pdf
Scientific Editor Work List	16835-Scientific editor work list.pdf