Publication Name	World Journal of Neurology
Manuscript ID	16878
Country	Jamaica

Received	2015-02-01 16:51
Peer-Review Started	2015-02-02 08:13
To Make the First Decision	2015-03-06 10:26
Return for Revision	2015-03-12 15:50
Revised	2015-03-30 01:01
Second Decision	2015-06-12 16:31
Accepted by Journal Editor-in-Chief	2015-06-15 01:17
Accepted by Company Editor-in-Chief	2015-07-08 15:25
Articles in Press	2015-07-08 15:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-23 11:42
Publish the Manuscript Online	2015-09-30 16:28

ISSN	2218-6212 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Neurosciences
Manuscript Type	Editorial
Article Title	Human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis: Clinical presentation and pathophysiology
Manuscript Source	Invited Manuscript
All Author List	Jean-Pierre Louboutin
Funding Agency and Grant Number
Corresponding Author	Jean-Pierre Louboutin, MD, PhD, Department of Basic Medical Sciences, University of the West Indies, Mona Campus, Kingston 7, Jamaica. jplouboutin@hotmail.com
Key Words	Tropical spastic paraparesis; Human T-cell lymphotropic virus type-1; Polymyositis; Animal models; Retroviruses; Myelopathy; Human T-cell lymphotropic virus type 1-associated myelopathy; Pathogenesis
Core Tip	Human T-cell lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a slowly progressive neurodegenerative disorder in which lesions of the central nervous system cause progressive weakness, stiffness, and a lower limb spastic paraparesis. There is no established treatment program for HAM/TSP. Prevention is difficult in low-income patients. Thus, there is a need for new therapeutic avenues that must be based on a better understanding, not only of clinical and clinicopathological data, but also of the pathophysiology of the affection. Consequently, a better understanding of existing or newly developed animal models of HAM/TSP is a prerequisite step in the development of new treatments.
Publish Date	2015-09-30 16:28
Citation	Louboutin JP. Human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis: Clinical presentation and pathophysiology. World J Neurol 2015; 5(3): 68-73
URL	http://www.wjgnet.com/2218-6212/full/v5/i3/68.htm
DOI	http://dx.doi.org/10.5316/wjn.v5.i3.68

Full Article (PDF)	WJN-5-68.pdf
Full Article (Word)	WJN-5-68.doc
Manuscript File	16878-Review.docx
Answering Reviewers	16878-Answering reviewers.pdf
Audio Core Tip	16878-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16878-Conflict-of-interest statement.pdf
Copyright License Agreement	16878-Copyright assignment.pdf
Peer-review Report	16878-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16878-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16878-Scientific misconduct check.pdf
Scientific Editor Work List	16878-Scientific editor work list.pdf