| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Engineering, Biomedical |
| Manuscript Type |
Basic Study |
| Article Title |
Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jorge Ribeiro, Tiago Pereira, Ana Rita Caseiro, Paulo Armada-da-Silva, Isabel Pires, Justina Prada, Irina Amorim, Sandra Amado, Miguel França, Carolina Gonçalves, Maria Ascensão Lopes, José Domingos Santos, Dina Morais Silva, Stefano Geuna, Ana Lúcia Luís and Ana Colette Maurício |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| DEXGELERATION: “Soluções avançadas de regeneração óssea com base em hidrogéis de dextrin” |
38853/2013 |
| European Community FEDER fund through ON2 - O Novo Norte - North Portugal Regional Operational Program 2007-2013 |
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| BEPIM II: “Microdispositivos biomédicos com capacidade osteointegrativa por μPIM” |
34128 |
| Program COMPETE - Programa Operacional Factores de Competitividade |
Pest-OE/AGR/UI0211/2011 |
| Program COMPETE - Programa Operacional Factores de Competitividade |
PTDC/CVT/103081/2008 |
| CDRsp’s Strategic Project |
UI-4044-2011-2012 (Pest-OE/EME/UI4044/2011) |
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| Corresponding Author |
Ana Colette Maurício, Professor, Departmento de Clínicas Veterinárias and +UPVet, Instituto de Ciências Biomédicas de Abel Salazar (ICBAS) and Centro de Estudos de Ciência Animal (CECA), Instituto de Ciências, Tecnologias e Agroambiente da Universidade do Porto (ICETA), Rua de Jorge Viterbo Ferreira, n° 228, 4050-313 Porto,
Portugal. ana.colette@hotmail.com
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| Key Words |
Nerve regeneration; Neurotmesis; Tube-guides; Mesenchymal stem cells; Carbon nanotubes; Functional assessment; Gait biomechanical analysis; Histomorfometry; Polyvinyl alcohol |
| Core Tip |
The rat sciatic injury neurotmesis injury model is an appropriate model to evaluate the nerve regeneration when electric conductive tube-guides of polyvinyl alcohol (PVA)-carbon nanotubes (CNTs) and PVA-polypyrrole (PPy) associated to mesenchymal stem cells (MSCs) are used as scaffolds. The results obtained revealed that treatment with MSCs associated to PVA-CNTs tube-guides induced an increased number of regenerated fibers and thickening of the myelin sheet. Functional and kinematics analysis revealed positive synergistic effects brought by MSCs and PVA-CNTs. The PVA-CNTs and PVA-PPy are promising scaffolds with electric conductive properties, bio- and cytocompatible that might prevent the secondary neurogenic muscular atrophy by improving the reestablishment of the neuro-muscular junction.
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| Publish Date |
2015-08-01 15:28 |
| Citation |
Ribeiro J, Pereira T, Caseiro AR, Armada-da-Silva P, Pires I, Prada J, Amorim I, Amado S, França M, Gonçalves C, Lopes MA, Santos JD, Silva DM, Geuna S, Luís AL, Maurício AC. Evaluation of biodegradable electric conductive tube-guides and mesenchymal stem cells. World J Stem Cells 2015; 7(6): 956-975 |
| URL |
http://www.wjgnet.com/1948-0210/full/v7/i6/956.htm |
| DOI |
http://dx.doi.org/10.4252/wjsc.v7.i6.956 |
