Publication Name	World Journal of Psychiatry
Manuscript ID	16984
Country	Canada

Received	2015-02-05 09:59
Peer-Review Started	2015-02-07 17:49
To Make the First Decision	2015-04-10 16:41
Return for Revision	2015-04-15 09:48
Revised	2015-04-30 08:00
Second Decision	2015-06-01 08:48
Accepted by Journal Editor-in-Chief	2015-06-03 20:46
Accepted by Executive Editor-in-Chief	2015-06-11 15:55
Articles in Press	2015-06-11 15:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-16 21:17
Publish the Manuscript Online	2015-09-27 17:16

ISSN	2220-3206 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Neurosciences
Manuscript Type	Frontier
Article Title	Role of presynaptic phosphoprotein synapsin II in schizophrenia
Manuscript Source	Invited Manuscript
All Author List	Luke Molinaro, Patricia Hui, Mattea Tan and Ram K Mishra
Funding Agency and Grant Number	Funding Agency Grant Number Canadian Institute of Health Research
Corresponding Author	Dr. Ram K Mishra, Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada. mishrar@mcmaster.ca
Key Words	Synapsin II; Schizophrenia; Dopamine; Glutamate; Neuropsychiatry; Antipsychotic drugs
Core Tip	The pre-synaptic phosphoprotein, synapsin II, is important in a variety of synaptic functions, including synaptogenesis and regulation of neurotransmitter release. Reduced levels of synapsin II in the prefrontal cortex of humans and animals have been found to confer susceptibility to schizophrenia (SZ). Disruptions in synapsin II gene expression, during development and/or adulthood, may cause synaptic dysfunction, resulting in neurotransmitter imbalances that likely contribute to the pathogenesis of SZ. Understanding synapsin II and its role in disease development will help unravel the pathogenic mechanisms of SZ, and may form the basis for use of novel therapeutics in the treatment of SZ.
Publish Date	2015-09-27 17:16
Citation	Molinaro L, Hui P, Tan M, Mishra RK. Role of presynaptic phosphoprotein synapsin II in schizophrenia. World J Psychiatr 2015; 5(3): 260-272
URL	http://www.wjgnet.com/2220-3206/full/v5/i3/260.htm
DOI	http://dx.doi.org/10.5498/wjp.v5.i3.260

Full Article (PDF)	WJP-5-260.pdf
Full Article (Word)	WJP-5-260.doc
Manuscript File	16984-Review.docx
Answering Reviewers	16984-Answering reviewers.pdf
Audio Core Tip	16984-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	16984-Conflict-of-interest statement.pdf
Copyright License Agreement	16984-Copyright assignment.pdf
Peer-review Report	16984-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	16984-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	16984-Scientific misconduct check.pdf
Scientific Editor Work List	16984-Scientific editor work list.pdf