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12/2/2015 11:45:00 AM | Browse: 383 | Download: 443
Publication Name World Journal of Psychiatry
Manuscript ID 16984
Country of Manuscript Source Canada
Received
2015-02-05 09:59
Peer-Review Started
2015-02-07 17:49
To Make the First Decision
2015-04-10 16:41
Return for Revision
2015-04-15 09:48
Revised
2015-04-30 08:00
Second Decision
2015-06-01 08:48
Accepted by Journal Editor-in-Chief
2015-06-03 20:46
Accepted by Company Editor-in-Chief
2015-06-11 15:55
Articles in Press
2015-06-11 15:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-09-16 21:17
Publish the Manuscript Online
2015-09-27 17:16
ISSN 2220-3206 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Neurosciences
Manuscript Type Frontier
Article Title Role of presynaptic phosphoprotein synapsin II in schizophrenia
Manuscript Source Invited Manuscript
All Author List Luke Molinaro, Patricia Hui, Mattea Tan and Ram K Mishra
Funding Agency and Grant Number
Funding Agency Grant Number
Canadian Institute of Health Research
Corresponding author Dr. Ram K Mishra, Department of Psychiatry and Behavioural Neurosciences, McMaster University, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada. mishrar@mcmaster.ca
Keywords Synapsin II; Schizophrenia; Dopamine; Glutamate; Neuropsychiatry; Antipsychotic drugs
Core Tip The pre-synaptic phosphoprotein, synapsin II, is important in a variety of synaptic functions, including synaptogenesis and regulation of neurotransmitter release. Reduced levels of synapsin II in the prefrontal cortex of humans and animals have been found to confer susceptibility to schizophrenia (SZ). Disruptions in synapsin II gene expression, during development and/or adulthood, may cause synaptic dysfunction, resulting in neurotransmitter imbalances that likely contribute to the pathogenesis of SZ. Understanding synapsin II and its role in disease development will help unravel the pathogenic mechanisms of SZ, and may form the basis for use of novel therapeutics in the treatment of SZ.
Publish Date 2015-09-27 17:16
Citation Molinaro L, Hui P, Tan M, Mishra RK. Role of presynaptic phosphoprotein synapsin II in schizophrenia. World J Psychiatr 2015; 5(3): 260-272
Url http://www.wjgnet.com/2220-3206/full/v5/i3/260.htm
DOI http://dx.doi.org/10.5498/wjp.v5.i3.260
Full Article (PDF) WJP-5-260.pdf
Full Article (Word) WJP-5-260.doc
Manuscript File 16984-Review.docx
Answering Reviewers 16984-Answering reviewers.pdf
Audio Core Tip 16984-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 16984-Conflict-of-interest statement.pdf
Copyright License Agreement 16984-Copyright assignment.pdf
Peer-review Report 16984-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 16984-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 16984-Scientific misconduct check.pdf
Scientific Editor Work List 16984-Scientific editor work list.pdf