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Articles Published Processes
9/18/2015 10:11:00 AM | Browse: 1025 | Download: 2251
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Received |
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2015-02-05 19:31 |
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Peer-Review Started |
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2015-02-07 08:43 |
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To Make the First Decision |
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2015-04-13 16:29 |
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Return for Revision |
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2015-04-15 15:35 |
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Revised |
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2015-04-30 21:06 |
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Second Decision |
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2015-07-02 21:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2015-07-03 16:55 |
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Articles in Press |
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2015-07-03 16:55 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-08-27 15:57 |
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Publish the Manuscript Online |
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2015-09-18 10:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Allergy |
| Manuscript Type |
Basic Study |
| Article Title |
Local corticosterone production and angiotensin-Ⅰ converting enzyme shedding in a mouse model of intestinal inflammation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hanne Salmenkari, Tomi Issakainen, Heikki Vapaatalo and Riitta Korpela |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Foundation for Clinical Chemistry Research, Finland (partly) |
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| Corresponding Author |
Heikki Vapaatalo, Professor Emeritus, Faculty of Medicine, Pharmacology, University of Helsinki, Haartmaninkatu 8, 00290 Helsinki, Finland. heikki.vapaatalo@helsinki.fi
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| Key Words |
Dextran sodium sulfate; Inflammation; Angiotensin-I converting enzyme; Local corticosterone; Intestine |
| Core Tip |
Soluble and tissue levels of angiotensin-Ⅰ?converting enzyme (ACE) along with corticosterone production were examined in a dextran sulfate mouse model of intestinal inflammation. Intestine is a site of ACE shedding, which is increased by inflammation. ACE and corticosterone are increased in intestinal incubations of morphologically disrupted and intact parts of the intestine. ACE product Ang Ⅱ stimulates corticosterone production in small intestine. The results suggest that intestinal Renin-Angiotensin system and glucocorticoids might be counter-regulatory systems in regulation of inflammatory processes in the intestine.
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| Publish Date |
2015-09-18 10:11 |
| Citation |
Salmenkari H, Issakainen T, Vapaatalo H, Korpela R. Local corticosterone production and angiotensin-Ⅰ converting enzyme shedding in a mouse model of intestinal inflammation. World J Gastroenterol 2015; 21(35): 10072-10079 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i35/10072.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i35.10072 |
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