| ISSN |
1949-8470 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Radiology, Nuclear Medicine & Medical Imaging |
| Manuscript Type |
Prospective Study |
| Article Title |
Cavernosal nerve functionality evaluation after magnetic resonance imaging-guided transurethral ultrasound treatment of the prostate
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Steffen Sammet, Ari Partanen, Ambereen Yousuf, Christina L Sammet, Emily V Ward, Craig Wardrip, Marek Niekrasz, Tatjana Antic, Aria Razmaria, Keyvan Farahani, Shunmugavelu Sokka, Gregory Karczmar and Aytekin Oto |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Cancer Institute Education and Career Development program R25 Cancer Nanotechnology in Imaging and Radiotherapy |
5R25CA132822-04(in part) |
| Cancer Research Foundation |
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| University of Chicago Comprehensive Cancer Center |
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| Philips Healthcare |
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| Corresponding Author |
Steffen Sammet, MD, PhD, DABR, FAMP, Associate Professor and Director of Clinical MR Physics, Department of Radiology, University of Chicago, 5841 South Maryland Avenue, MC2026, Chicago, IL 60615,
United States. ssammet@uchicago.edu
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| Key Words |
Ultrasound therapy; Thermal tissue ablation; Prostate; Magnetic resonance imaging guided therapy; Intra-operative; Histology; Validation |
| Core Tip |
Therapeutic ultrasound is a promising treatment modality for minimally invasive thermal ablation of tissue. This study assessed a novel trans-urethral ultrasound therapy device with magnetic resonance imaging (MRI) guidance to ablate canine prostate tissue in vivo. Real-time temperature monitoring and thermotherapy feed-back control was performed in a clinical 3T whole-body MR scanner. Post-treatment evaluation of caver-nous nerve functionality was performed with a nerve stimulator. Treatment accuracy was assessed by correlation of treatment planning, thermal dose maps, and histo-pathological results. Regions of thermal ablation were limited to areas within the prostate capsule and no damage was observed in adjacent anatomical structures. These results indicate that MRI-guided transurethral ultrasound therapy can accurately ablate prostatic regions with minimal damage to surrounding tissue.
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| Publish Date |
2015-12-28 08:56 |
| Citation |
Sammet S, Partanen A, Yousuf A, Sammet CL, Ward EV, Wardrip C, Niekrasz M, Antic T, Razmaria A, Farahani K, Sokka S, Karczmar G, Oto A. Cavernosal nerve functionality evaluation after magnetic resonance imaging-guided transurethral ultrasound treatment of the prostate. World J Radiol 2015; 7(12): 521-530 |
| URL |
http://www.wjgnet.com/1949-8470/full/v7/i12/521.htm |
| DOI |
http://dx.doi.org/10.4329/wjr.v7.i12.521 |
