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12/28/2015 8:56:00 AM | Browse: 335 | Download: 610
Publication Name World Journal of Radiology
Manuscript ID 17024
Country of Manuscript Source United States
Received
2015-02-07 08:30
Peer-Review Started
2015-02-08 16:20
To Make the First Decision
2015-05-13 19:14
Return for Revision
2015-05-19 17:04
Revised
2015-06-15 05:49
Second Decision
2015-11-12 14:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-11-25 17:00
Articles in Press
2015-11-25 17:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-12-22 21:08
Publish the Manuscript Online
2015-12-28 08:56
ISSN 1949-8470 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Radiology, Nuclear Medicine and Medical Imaging
Manuscript Type Prospective Study
Article Title Cavernosal nerve functionality evaluation after magnetic resonance imaging-guided transurethral ultrasound treatment of the prostate
Manuscript Source Unsolicited Manuscript
All Author List Steffen Sammet, Ari Partanen, Ambereen Yousuf, Christina L Sammet, Emily V Ward, Craig Wardrip, Marek Niekrasz, Tatjana Antic, Aria Razmaria, Keyvan Farahani, Shunmugavelu Sokka, Gregory Karczmar and Aytekin Oto
Funding Agency and Grant Number
Funding Agency Grant Number
National Cancer Institute Education and Career Development program R25 Cancer Nanotechnology in Imaging and Radiotherapy 5R25CA132822-04(in part)
Cancer Research Foundation
University of Chicago Comprehensive Cancer Center
Philips Healthcare
Corresponding author Steffen Sammet, MD, PhD, DABR, FAMP, Associate Professor and Director of Clinical MR Physics, Department of Radiology, University of Chicago, 5841 South Maryland Avenue, MC2026, Chicago, IL 60615, United States. ssammet@uchicago.edu
Keywords Ultrasound therapy; Thermal tissue ablation; Prostate; Magnetic resonance imaging guided therapy; Intra-operative; Histology; Validation
Core Tip Therapeutic ultrasound is a promising treatment modality for minimally invasive thermal ablation of tissue. This study assessed a novel trans-urethral ultrasound therapy device with magnetic resonance imaging (MRI) guidance to ablate canine prostate tissue in vivo. Real-time temperature monitoring and thermotherapy feed-back control was performed in a clinical 3T whole-body MR scanner. Post-treatment evaluation of caver-nous nerve functionality was performed with a nerve stimulator. Treatment accuracy was assessed by correlation of treatment planning, thermal dose maps, and histo-pathological results. Regions of thermal ablation were limited to areas within the prostate capsule and no damage was observed in adjacent anatomical structures. These results indicate that MRI-guided transurethral ultrasound therapy can accurately ablate prostatic regions with minimal damage to surrounding tissue.
Publish Date 2015-12-28 08:56
Citation Sammet S, Partanen A, Yousuf A, Sammet CL, Ward EV, Wardrip C, Niekrasz M, Antic T, Razmaria A, Farahani K, Sokka S, Karczmar G, Oto A. Cavernosal nerve functionality evaluation after magnetic resonance imaging-guided transurethral ultrasound treatment of the prostate. World J Radiol 2015; 7(12): 521-530
Url http://www.wjgnet.com/1949-8470/full/v7/i12/521.htm
DOI http://dx.doi.org/10.4329/wjr.v7.i12.521
Full Article (PDF) WJR-7-521.pdf
Full Article (Word) WJR-7-521.doc
Manuscript File 17024-Review.docx
Answering Reviewers 17024-Answering reviewers.pdf
Audio Core Tip 17024-Audio core tip.mp3
Biostatistics Review Certificate 17024-Biostatistics statement.pdf
Clinical Trial Registration Statement 17024-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form 17024-Conflict-of-interest statement.pdf
Copyright License Agreement 17024-Copyright assignment.pdf
Data Sharing Statement 17024-Data sharing statement.pdf
Signed Informed Consent Form(s) or Document(s) 17024-Clinical trial registration statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document Institutional_Animal_Care_and_Use_Committee_Statement_20150207081149.pdf
Institutional Review Board Approval Form or Document 17024-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 17024-Language certificate.pdf
Peer-review Report 17024-Peer-review(s).pdf
Scientific Misconduct Check 17024-Scientific misconduct check.pdf
Scientific Editor Work List 17024-Scientific editor work list.pdf