Publication Name	World Journal of Clinical Infectious Diseases
Manuscript ID	17056
Country	Netherlands

Received	2015-02-09 17:50
Peer-Review Started	2015-02-10 16:40
To Make the First Decision	2015-03-06 10:09
Return for Revision	2015-03-15 18:56
Revised	2015-04-20 20:18
Second Decision	2015-06-01 14:39
Accepted by Journal Editor-in-Chief	2015-06-01 15:34
Accepted by Executive Editor-in-Chief	2015-06-11 16:07
Articles in Press	2015-06-11 16:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-28 14:14
Publish the Manuscript Online	2015-11-27 16:31

ISSN	2220-3176 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Infectious Diseases
Manuscript Type	Basic Study
Article Title	Tuf mRNA rather than 16S rRNA is associated with culturable Staphylococcus aureus
Manuscript Source	Invited Manuscript
All Author List	Anne JM Loonen, Petra FG Wolffs, Maikel de Bresser, Maurice Habraken, Cathrien A Bruggeman, Mirjam HA Hermans and Adriaan JC van den Brule
Funding Agency and Grant Number
Corresponding Author	Adriaan JC van den Brule, PhD, Laboratory for Molecular Diagnostics, Department of Medical Microbiology and Pathology, Jeroen Bosch Hospital, Box 90153, 5200 ME ‘s-Hertogenbosch, The Netherlands. a.v.d.brule@jbz.nl
Key Words	Bloodstream infection; Staphylococcus aureus; Viability; mRNA; Polymerase chain reaction; Sepsis; Molecular diagnostics; Blood
Core Tip	We report our first results from a proof-of-principle study where we show that tuf mRNA expression seems to correlate with active Staphylococcus aureus (S. aureus) infection. The commonly used target, 16S rRNA, seems unsuitable for viability measurements as it can be detected from samples containing unculturable bacteria. This study indicates that tuf mRNA expression is associated with viable S. aureus, as determined by culture.
Publish Date	2015-11-27 16:31
Citation	Loonen AJM, Wolffs PFG, de Bresser M, Habraken M, Bruggeman CA, Hermans MHA, van den Brule AJC. Tuf mRNA rather than 16S rRNA is associated with culturable Staphylococcus aureus. World J Clin Infect Dis 2015; 5(4): 86-93
URL	http://www.wjgnet.com/2220-3176/full/v5/i4/86.htm
DOI	http://dx.doi.org/10.5495/wjcid.v5.i4.86

Full Article (PDF)	WJCID-5-86.pdf
Full Article (Word)	WJCID-5-86.doc
Manuscript File	17056-Review.doc
Answering Reviewers	17056-Answering reviewers.pdf
Audio Core Tip	17056-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	17056-Conflict-of-interest statement.pdf
Copyright License Agreement	17056-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	17056-Institutional animal care and use committee statement.pdf
Peer-review Report	17056-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17056-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17056-Scientific misconduct check.pdf
Scientific Editor Work List	17056-Scientific editor work list.pdf