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Articles Published Processes
7/30/2015 11:19:00 AM | Browse: 1392 | Download: 3114
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Received |
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2015-02-10 09:11 |
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Peer-Review Started |
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2015-02-10 11:35 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2015-03-17 11:26 |
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Revised |
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2015-04-03 17:47 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2015-05-11 08:44 |
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Second Decision by Editor-in-Chief |
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2015-05-11 18:03 |
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Final Decision by Editorial Office Director |
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2015-05-21 17:44 |
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Articles in Press |
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2015-05-21 17:44 |
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Edit the Manuscript by Language Editor |
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2015-06-04 17:31 |
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Typeset the Manuscript |
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2015-07-13 16:09 |
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Publish the Manuscript Online |
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2015-07-30 11:17 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Basic Study |
| Article Title |
TLR4 upregulates CBS expression through NF-kB activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bo Yuan, Wei-Hong Tang, Li-Juan Lu, Yuan Zhou, Hong-Yan Zhu, You-Lang Zhou, Hong-Hong Zhang, Chuang-Ying Hu and Guang-Yin Xu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81230024 |
| National Natural Science Foundation of China |
81471137 (to GYX) |
| National Natural Science Foundation of China |
31400947 (to HHZ) |
| Priority Academic Program Development of Jiangsu Higher Education Institutions |
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| Corresponding Author |
Guang-Yin Xu, MD, PhD, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, Institute of Neuroscience, The Second Affiliated Hospital, Soochow University, 199 Ren-Ai Road, Suzhou 215123, Jiangsu Province, China. guangyinxu@suda.edu.cn |
| Key Words |
Irritable bowel syndrome; Dorsal root ganglion; Visceral hypersensitivity; Hydrogen sulfide; Toll-like receptors; Nuclear factor-kappa B |
| Core Tip |
This study investigated the roles of toll-like receptor 4 (TLR4) and its signaling pathway in the pathogenesis of visceral hypersensitivity in a rat model of irritable bowel syndrome (IBS). We demonstrated that activation of TLR4 upregulates the expression of the endogenous hydrogen sulfide-synthesizing enzyme cystathionine β synthetase. This upregulation was mediated by enhanced translocation of nuclear factor-kB in dorsal root ganglion cells, through which it contributed to the visceral hypersensitivity in IBS-like rats. Our results suggest TLR4 plays a major role in the development of functional visceral pain and hence suggest a novel mechanism and potential therapeutic target for the treatment of chronic visceral pain in patients with IBS. |
| Publish Date |
2015-07-30 11:17 |
| Citation |
Yuan B, Tang WH, Lu LJ, Zhou Y, Zhu HY, Zhou YL, Zhang HH, Hu CY, Xu GY. TLR4 upregulates CBS expression through NF-B activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity. World J Gastroenterol 2015; 21(28): 8615-8628
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| URL |
http://www.wjgnet.com/1007-9327/full/v21/i28/8615.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i28.8615 |
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