Publication Name	World Journal of Gastroenterology
Manuscript ID	17058
Country	China

Received	2015-02-10 09:11
Peer-Review Started	2015-02-10 11:35
To Make the First Decision	2015-03-10 19:56
Return for Revision	2015-03-17 11:26
Revised	2015-04-03 17:47
Second Decision	2015-05-11 08:44
Accepted by Journal Editor-in-Chief	2015-05-11 18:03
Accepted by Executive Editor-in-Chief	2015-05-21 17:44
Articles in Press	2015-05-21 17:44
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-06-04 17:31
Typeset the Manuscript	2015-07-13 16:09
Publish the Manuscript Online	2015-07-30 11:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Neurosciences
Manuscript Type	Basic Study
Article Title	TLR4 upregulates CBS expression through NF-kB activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity
Manuscript Source	Unsolicited Manuscript
All Author List	Bo Yuan, Wei-Hong Tang, Li-Juan Lu, Yuan Zhou, Hong-Yan Zhu, You-Lang Zhou, Hong-Hong Zhang, Chuang-Ying Hu and Guang-Yin Xu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81230024 National Natural Science Foundation of China 81471137 (to GYX) National Natural Science Foundation of China 31400947 (to HHZ) Priority Academic Program Development of Jiangsu Higher Education Institutions
Corresponding Author	Guang-Yin Xu, MD, PhD, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, Institute of Neuroscience, The Second Affiliated Hospital, Soochow University, 199 Ren-Ai Road, Suzhou 215123, Jiangsu Province, China. guangyinxu@suda.edu.cn
Key Words	Irritable bowel syndrome; Dorsal root ganglion; Visceral hypersensitivity; Hydrogen sulfide; Toll-like receptors; Nuclear factor-kappa B
Core Tip	This study investigated the roles of toll-like receptor 4 (TLR4) and its signaling pathway in the pathogenesis of visceral hypersensitivity in a rat model of irritable bowel syndrome (IBS). We demonstrated that activation of TLR4 upregulates the expression of the endogenous hydrogen sulfide-synthesizing enzyme cystathionine β synthetase. This upregulation was mediated by enhanced translocation of nuclear factor-kB in dorsal root ganglion cells, through which it contributed to the visceral hypersensitivity in IBS-like rats. Our results suggest TLR4 plays a major role in the development of functional visceral pain and hence suggest a novel mechanism and potential therapeutic target for the treatment of chronic visceral pain in patients with IBS.
Publish Date	2015-07-30 11:17
Citation	Yuan B, Tang WH, Lu LJ, Zhou Y, Zhu HY, Zhou YL, Zhang HH, Hu CY, Xu GY. TLR4 upregulates CBS expression through NF-B activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity. World J Gastroenterol 2015; 21(28): 8615-8628
URL	http://www.wjgnet.com/1007-9327/full/v21/i28/8615.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i28.8615

Full Article (PDF)	WJG-21-8615.pdf
Full Article (Word)	WJG-21-8615.doc
Manuscript File	17058-Review.doc
Answering Reviewers	17058-Answering reviewers.pdf
Audio Core Tip	17058-Audio core tip.mp3
Biostatistics Review Certificate	17058-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	17058-Conflict-of-interest statement.pdf
Copyright License Agreement	17058-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	17058-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	17058-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	17058-Language certificate.pdf
Peer-review Report	17058-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17058-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17058-Scientific misconduct check.pdf
Scientific Editor Work List	17058-Scientific editor work list.pdf