| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Basic Study |
| Article Title |
Influence of perfusate on liver viability during hypothermic machine perfusion
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Jun Jia, Jing Zhang, Jian-Hui Li, Xu-Dong Chen, Li Jiang, Yan-Fei Zhou, Ning He, Hai-Yang Xie, Lin Zhou and Shu-Sen Zheng |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Science and Technology Major Project of China |
2012ZX10002-017 |
| Science Fund for Creative Research Groups of the National Natural Science Foundation of China |
81121002 |
| National Natural Science Foundation of China |
81000137 |
| National Natural Science Foundation of China |
81470891 |
| Qianjiang Talent Program of Zhejiang Province, China |
2012R10045 |
| Scientific Research Program for the Returned Overseas Chinese Scholars, Ministry of Health of China |
J20112008 |
| National High-tech R&D Program of China (863 Program) |
2015AA020923 |
| Ministry of Education, Zhejiang Province, China |
Y201328095 |
|
| Corresponding Author |
Shu-Sen Zheng, MD, PhD, FACS, Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, No. 79 Qingchun Road, Hangzhou 310003, Zhejiang Province, China. shusenzheng@zju.edu.cn |
| Key Words |
Hypothermic machine perfusion; Static cold storage; Liver viability; Wisconsin cold-storage solution; Histidine-tryptophan-ketoglutarate solution |
| Core Tip |
Although static cold storage (SCS) is the gold standard for liver transplantation, hypothermic machine perfusion (HMP) is currently challenging the limitations of SCS. However, there is no consensus on the basic setting for HMP, including the ideal perfusate. Here we compared the most common preservation solutions [University of Wisconsin cold-storage solution and histidine-tryptophan-ketoglutarate solution (HTK), saline as control] and found that HMP is superior to SCS regardless of different solutions and HTK seems to be the optimal perfusate for HMP. |
| Publish Date |
2015-08-08 15:26 |
| Citation |
Jia JJ, Zhang J, Li JH, Chen XD, Jiang L, Zhou YF, He N, Xie HY, Zhou L, Zheng SS. Influence of perfusate on liver viability during hypothermic machine perfusion. World J Gastroenterol 2015; 21(29): 8848-8857 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i29/8848.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i29.8848 |
