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Articles Published Processes
9/18/2015 10:11:00 AM | Browse: 1304 | Download: 2234
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Received |
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2015-02-21 10:00 |
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Peer-Review Started |
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2015-02-22 20:06 |
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To Make the First Decision |
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2015-03-26 17:02 |
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Return for Revision |
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2015-04-01 11:42 |
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Revised |
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2015-05-25 21:41 |
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Second Decision |
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2015-06-23 18:21 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-07-03 17:09 |
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Articles in Press |
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2015-07-03 17:09 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-08-28 09:17 |
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Publish the Manuscript Online |
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2015-09-18 10:11 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kazutaka Yoshida, Yusuke Ushida, Tomoko Ishijima, Hiroyuki Suganuma, Takahiro Inakuma, Nobuhiro Yajima, Keiko Abe and Yuji Nakai |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Kagome Co. Ltd |
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| Corresponding Author |
Kazutaka Yoshida, Scientist, Research and Development Division, Kagome Co., Ltd., 17 Nishitomiyama, Nasushiobara 329-2762, Japan. kazutaka_yoshida@kagome.co.jp |
| Key Words |
Broccoli sprout; Glucoraphanin; Sulforaphane; DNA microarray; Acetaminophen; Galactosamine; Acute liver injury |
| Core Tip |
The aim of this study was to investigate the effects of broccoli sprout extract (BSEx) on gene expression and acute liver injury in rat liver. Gene expression analyses revealed that BSEx upregulated the expression of genes related to detoxification and glutathione synthesis. Experiments using acute liver injury models revealed that BSEx suppressed acetaminophen- and D-galactosamine-induced liver injury and increased liver glutathione concentration and glutathione-S-transferase activity. These findings suggest that consuming BSEx daily protected the liver from various types of xenobiotic substances through induction of detoxification enzymes and glutathione synthesis. |
| Publish Date |
2015-09-18 10:11 |
| Citation |
Yoshida K, Ushida Y, Ishijima T, Suganuma H, Inakuma T, Yajima N, Abe K, Nakai Y. Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury. World J Gastroenterol 2015; 21(35): 10091-10103 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i35/10091.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i35.10091 |
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