Publication Name	World Journal of Gastroenterology
Manuscript ID	17152
Country	Japan

Received	2015-02-21 20:25
Peer-Review Started	2015-02-23 09:17
To Make the First Decision	2015-03-10 20:01
Return for Revision	2015-03-17 11:20
Revised	2015-04-09 01:15
Second Decision	2015-05-04 08:25
Accepted by Journal Editor-in-Chief	2015-05-04 14:54
Accepted by Executive Editor-in-Chief	2015-05-07 16:01
Articles in Press	2015-05-07 16:02
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-07-17 03:20
Typeset the Manuscript	2015-08-17 16:46
Publish the Manuscript Online	2015-09-14 16:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Allergy
Manuscript Type	Retrospective Study
Article Title	Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Katsunobu Sakurai, Sadaaki Yamazoe, Kenjiro Kimura, Takahiro Toyokawa, Ryosuke Amano, Hiroaki Tanaka, Kazuya Muguruma and Kosei Hirakawa
Funding Agency and Grant Number
Corresponding Author	Masatsune Shibutani, MD, PhD, Department of Surgical Oncology, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-Ku, Osaka City, Osaka Prefecture, Osaka 5458585, Japan. fbxbj429@ybb.ne.jp
Key Words	Colorectal cancer; Prognosis; Unresectable; Chemotherapy; Lymphocyte to monocyte ratio
Core Tip	We retrospectively analyzed 104 patients who had unresectable metastatic colorectal cancer. This study indicated that patients with a low pre-treatment lymphocyte to monocyte ratio (LMR) had a significantly worse overall survival rate. Moreover, patients who demonstrated low pre-treatment LMR and normalization after chemotherapy exhibited a better overall survival rate than patients with low pre-treatment and post-treatment LMR values.
Publish Date	2015-09-14 16:54
Citation	Shibutani M, Maeda K, Nagahara H, Ohtani H, Sakurai K, Yamazoe S, Kimura K, Toyokawa T, Amano R, Tanaka H, Muguruma K, Hirakawa K. Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer. World J Gastroenterol 2015; 21(34): 9966-9973
URL	http://www.wjgnet.com/1007-9327/full/v21/i34/9966.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i34.9966

Full Article (PDF)	WJG-21-9966.pdf
Full Article (Word)	WJG-21-9966.doc
Manuscript File	17152-Review.docx
Answering Reviewers	17152-Answering reviewers.pdf
Audio Core Tip	17152-Audio core tip.wav
Biostatistics Review Certificate	17152-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	17152-Conflict-of-interest statement.pdf
Copyright License Agreement	17152-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	17152-Institutional review board statement.pdf
Peer-review Report	17152-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17152-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17152-Scientific misconduct check.pdf
Scientific Editor Work List	17152-Scientific editor work list.pdf