Publication Name	World Journal of Gastroenterology
Manuscript ID	1716
Country	China

Received	2012-12-31 08:34
Peer-Review Started	2012-12-31 09:57
To Make the First Decision	2013-01-05 14:15
Return for Revision	2013-01-07 11:28
Revised	2013-01-07 22:09
Second Decision	2013-02-28 18:48
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-03-01 06:29
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-04-10 09:58
Publish the Manuscript Online	2013-04-19 20:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Biochemistry & Molecular Biology
Manuscript Type	Autobiography
Article Title	Elevated serum levels of human relaxin-2 in patients with esophageal squamous cell carcinoma
Manuscript Source	Invited Manuscript
All Author List	Peng Ren, Zhen-Tao Yu, Li Xiu, Mei Wang and Hua-Min Liu
Funding Agency and Grant Number
Corresponding Author	Zhen-Tao Yu, MD, Department of Esophageal Cancer, Tianjin Medical University Cancer Institute and Hospital and Key Laboratory of Cancer Prevention and Therapy, Huanhu West Road, Tianjin 300060, China. renpengtj@126.com
Key Words	Esophageal squamous cell carcinoma; Relaxin; Tumor markers; Metastasis
Core Tip	Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive carcinomas of the gastrointestinal tract. Despite improvements in detection, surgical resection, and (neo-) adjuvant therapy, the overall survival of ESCC patients remains lower than that of patients with other solid tumors due to distant metastasis. Therefore, it is important to detect disease progression and metastasis as early as possible to improve timely treatment and improve survival. In this study, the authors assessed the prognostic value of serum human relaxin 2 (H2 RLN) level in patients with ESCC, and found that serum concentrations of H2 RLN were elevated in ESCC patients and were correlated with disease metastasis and survival. Serum concentrations of H2 RLN may be an important prognostic marker in ESCC patients.
Publish Date	2013-04-19 20:42
Citation	Ren P, Yu ZT, Xiu L, Wang M, Liu HM. Elevated serum levels of human relaxin-2 in patients with esophageal squamous cell carcinoma. World J Gastroenterol 2013; 19(15): 2412-2418
URL	http://www.wjgnet.com/1007-9327/full/v19/i15/2412.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i15.2412

Full Article (PDF)	WJG-19-2412.pdf
Manuscript File	1716-Review.doc
Answering Reviewers	1716-Answering reviewers.doc
Copyright License Agreement	1716-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	1716-Language certificate.doc
Peer-review Report	1716-Peer review(s).docx
Scientific Editor Work List	1716-Scientific editor work list.doc