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7/8/2015 12:00:00 PM | Browse: 531 | Download: 599
Publication Name World Journal of Gastroenterology
Manuscript ID 17167
Country/Territory Norway
Received
2015-02-22 03:05
Peer-Review Started
2015-02-28 08:40
To Make the First Decision
2015-03-26 18:29
Return for Revision
2015-03-28 20:11
Revised
2015-03-31 04:46
Second Decision
2015-05-18 08:56
Accepted by Journal Editor-in-Chief
2015-05-18 18:53
Accepted by Company Editor-in-Chief
2015-05-21 17:33
Articles in Press
2015-05-21 17:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-06-25 10:25
Publish the Manuscript Online
2015-07-08 12:01
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Editorial
Article Title Recent developments in the pathophysiology of irritable bowel syndrome
Manuscript Source Invited Manuscript
All Author List Magdy El-Salhy
Funding Agency and Grant Number
Funding Agency Grant Number
Helse-Vest and Helse-Fonna, Norway
Corresponding author Magdy El-Salhy, Professor, Consultant Gastroenterologist, Section for Gastroenterology, Department of Medicine, Stord Hospital, Box 4000, 5409 Stord, Norway. magdy.el-salhy@helse-fonna.no
Keywords Diet; Endocrine cells; Genetic factors; Low-grade inflammation; Microbiota; Stem cells
Core Tip There are several factors that play a major role in the pathophysiology of irritable bowel syndrome (IBS). These factors are genetic disposition, diet, the intestinal microbiota, and mucosal low-grade inflammation. These factors are known to affect the gastrointestinal endocrine cells, with the densities of intestinal endocrine cells being reduced in IBS patients. The reduction in the gastrointestinal endocrine cells seems to be caused by abnormal clonogenic and differentiation activities of the intestinal stem cells. The abnormalities in the gastrointestinal endocrine cells can explain the visceral hypersensitivity, disturbed gastrointestinal motility, and abnormal gut secretion observed in IBS patients.
Publish Date 2015-07-08 12:01
Citation El-Salhy M. Recent developments in the pathophysiology of irritable bowel syndrome. World J Gastroenterol 2015; 21(25): 7621-7636
Url http://www.wjgnet.com/1007-9327/full/v21/i25/7621.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i25.7621
Full Article (PDF) WJG-21-7621.pdf
Full Article (Word) WJG-21-7621.doc
Manuscript File 17167-Review.doc
Answering Reviewers 17167-Answering reviewers.pdf
Audio Core Tip 17167-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 17167-Conflict-of-interest statement.pdf
Copyright License Agreement 17167-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 17167-Language certificate.pdf
Peer-review Report 17167-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 17167-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 17167-Scientific misconduct check.pdf
Scientific Editor Work List 17167-Scientific editor work list.pdf