Publication Name	World Journal of Gastroenterology
Manuscript ID	17167
Country	Norway

Received	2015-02-22 03:05
Peer-Review Started	2015-02-28 08:40
To Make the First Decision	2015-03-26 18:29
Return for Revision	2015-03-28 20:11
Revised	2015-03-31 04:46
Second Decision	2015-05-18 08:56
Accepted by Journal Editor-in-Chief	2015-05-18 18:53
Accepted by Company Editor-in-Chief	2015-05-21 17:33
Articles in Press	2015-05-21 17:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-25 10:25
Publish the Manuscript Online	2015-07-08 12:01

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Recent developments in the pathophysiology of irritable bowel syndrome
Manuscript Source	Invited Manuscript
All Author List	Magdy El-Salhy
Funding Agency and Grant Number	Funding Agency Grant Number Helse-Vest and Helse-Fonna, Norway
Corresponding Author	Magdy El-Salhy, Professor, Consultant Gastroenterologist, Section for Gastroenterology, Department of Medicine, Stord Hospital, Box 4000, 5409 Stord, Norway. magdy.el-salhy@helse-fonna.no
Key Words	Diet; Endocrine cells; Genetic factors; Low-grade inflammation; Microbiota; Stem cells
Core Tip	There are several factors that play a major role in the pathophysiology of irritable bowel syndrome (IBS). These factors are genetic disposition, diet, the intestinal microbiota, and mucosal low-grade inflammation. These factors are known to affect the gastrointestinal endocrine cells, with the densities of intestinal endocrine cells being reduced in IBS patients. The reduction in the gastrointestinal endocrine cells seems to be caused by abnormal clonogenic and differentiation activities of the intestinal stem cells. The abnormalities in the gastrointestinal endocrine cells can explain the visceral hypersensitivity, disturbed gastrointestinal motility, and abnormal gut secretion observed in IBS patients.
Publish Date	2015-07-08 12:01
Citation	El-Salhy M. Recent developments in the pathophysiology of irritable bowel syndrome. World J Gastroenterol 2015; 21(25): 7621-7636
URL	http://www.wjgnet.com/1007-9327/full/v21/i25/7621.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i25.7621

Full Article (PDF)	WJG-21-7621.pdf
Full Article (Word)	WJG-21-7621.doc
Manuscript File	17167-Review.doc
Answering Reviewers	17167-Answering reviewers.pdf
Audio Core Tip	17167-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	17167-Conflict-of-interest statement.pdf
Copyright License Agreement	17167-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	17167-Language certificate.pdf
Peer-review Report	17167-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17167-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17167-Scientific misconduct check.pdf
Scientific Editor Work List	17167-Scientific editor work list.pdf