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Articles Published Processes
12/15/2015 12:22:00 PM | Browse: 957 | Download: 1778
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Received |
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2015-02-23 15:36 |
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Peer-Review Started |
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2015-02-24 09:36 |
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To Make the First Decision |
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2015-03-26 18:08 |
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Return for Revision |
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2015-03-30 13:47 |
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Revised |
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2015-04-13 14:38 |
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Second Decision |
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2015-09-28 16:02 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-09-30 10:00 |
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Articles in Press |
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2015-09-30 10:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-11-16 12:52 |
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Typeset the Manuscript |
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2015-12-02 17:25 |
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Publish the Manuscript Online |
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2015-12-15 12:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Characteristics of symptomatic reflux episodes in Japanese proton pump inhibitor-refractory non-erosive reflux disease patients
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kenichiro Nakagawa, Tomoyuki Koike, Katsunori Iijima, Masahiro Saito, Hiroki Kikuchi, Waku Hatta, Nobuyuki Ara, Kaname Uno, Naoki Asano and Tooru Shimosegawa |
| Funding Agency and Grant Number |
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| Corresponding Author |
Tomoyuki Koike, MD, PhD, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi Aoba-ku, Sendai Miyagi 980-8574, Japan. tkoike@rd5.so-net.ne.jp |
| Key Words |
Proton pump inhibitor; Symptomatic reflux episodes; Proximal reflux; Non-erosive reflux disease; Impedance-pH monitoring |
| Core Tip |
Thirty-five non-erosive reflux disease patients with persistent symptoms, despite taking rabeprazole 10 mg twice daily, were included. In 14 (40%) symptom index (SI)-positive patients, with liquid weakly acid reflux, the occurrence rate of reflux symptoms in pro-ximal reflux episodes was significantly more frequent (46.7%) than in distal ones (5.7%) (P < 0.001). With mixed liquid-gas weakly acid reflux, the occurrence rate of reflux symptoms in proximal reflux episodes was significantly more frequent (31.0%) than in distal reflux ones (3.3%) (P < 0.001). The proximal extent of weakly acidic liquid and mixed liquid-gas reflux is a major factor of reflux perception in SI-positive patients on proton pump inhibitor (PPI).
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| Publish Date |
2015-12-15 12:22 |
| Citation |
Nakagawa K, Koike T, Iijima K, Saito M, Kikuchi H, Hatta W, Ara N, Uno K, Asano N, Shimosegawa T. Characteristics of symptomatic reflux episodes in Japanese proton pump inhibitor-refractory non-erosive reflux disease patients. World J Gastroenterol 2015; 21(47): 13352-13359 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i47/13352.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i47.13352 |
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