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12/15/2015 12:22:00 PM | Browse: 837 | Download: 1403
Publication Name World Journal of Gastroenterology
Manuscript ID 17196
Country/Territory Japan
Received
2015-02-23 15:36
Peer-Review Started
2015-02-24 09:36
To Make the First Decision
2015-03-26 18:08
Return for Revision
2015-03-30 13:47
Revised
2015-04-13 14:38
Second Decision
2015-09-28 16:02
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-09-30 10:00
Articles in Press
2015-09-30 10:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-11-16 12:52
Typeset the Manuscript
2015-12-02 17:25
Publish the Manuscript Online
2015-12-15 12:22
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Characteristics of symptomatic reflux episodes in Japanese proton pump inhibitor-refractory non-erosive reflux disease patients
Manuscript Source Unsolicited Manuscript
All Author List Kenichiro Nakagawa, Tomoyuki Koike, Katsunori Iijima, Masahiro Saito, Hiroki Kikuchi, Waku Hatta, Nobuyuki Ara, Kaname Uno, Naoki Asano and Tooru Shimosegawa
Funding Agency and Grant Number
Corresponding Author Tomoyuki Koike, MD, PhD, Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi Aoba-ku, Sendai Miyagi 980-8574, Japan. tkoike@rd5.so-net.ne.jp
Key Words Proton pump inhibitor; Symptomatic reflux episodes; Proximal reflux; Non-erosive reflux disease; Impedance-pH monitoring
Core Tip Thirty-five non-erosive reflux disease patients with persistent symptoms, despite taking rabeprazole 10 mg twice daily, were included. In 14 (40%) symptom index (SI)-positive patients, with liquid weakly acid reflux, the occurrence rate of reflux symptoms in pro-ximal reflux episodes was significantly more frequent (46.7%) than in distal ones (5.7%) (P < 0.001). With mixed liquid-gas weakly acid reflux, the occurrence rate of reflux symptoms in proximal reflux episodes was significantly more frequent (31.0%) than in distal reflux ones (3.3%) (P < 0.001). The proximal extent of weakly acidic liquid and mixed liquid-gas reflux is a major factor of reflux perception in SI-positive patients on proton pump inhibitor (PPI).
Publish Date 2015-12-15 12:22
Citation Nakagawa K, Koike T, Iijima K, Saito M, Kikuchi H, Hatta W, Ara N, Uno K, Asano N, Shimosegawa T. Characteristics of symptomatic reflux episodes in Japanese proton pump inhibitor-refractory non-erosive reflux disease patients. World J Gastroenterol 2015; 21(47): 13352-13359
URL http://www.wjgnet.com/1007-9327/full/v21/i47/13352.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i47.13352
Full Article (PDF) WJG-21-13352.pdf
Full Article (Word) WJG-21-13352.doc
Manuscript File 17196-Review.docx
Answering Reviewers 17196-Answering reviewers.pdf
Audio Core Tip 17196-Audio core tip.wma
Biostatistics Review Certificate 17196-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 17196-Conflict-of-interest statement.pdf
Copyright License Agreement 17196-Copyright assignment.pdf
Institutional Review Board Approval Form or Document 17196-Institutional review board statement.pdf
Peer-review Report 17196-Peer-review(s).pdf
Scientific Misconduct Check 17196-Scientific misconduct check.pdf
Scientific Editor Work List 17196-Scientific editor work list.pdf