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9/28/2015 6:06:00 PM | Browse: 448 | Download: 784
Publication Name World Journal of Gastroenterology
Manuscript ID 17212
Country of Manuscript Source Spain
Received
2015-02-25 10:25
Peer-Review Started
2015-02-26 11:52
To Make the First Decision
2015-04-13 15:50
Return for Revision
2015-04-14 10:36
Revised
2015-04-18 04:13
Second Decision
2015-07-07 22:29
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-07-08 17:54
Articles in Press
2015-07-08 17:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-09-21 16:28
Publish the Manuscript Online
2015-09-28 18:06
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Retrospective Study
Article Title Plasma betatrophin levels in patients with liver cirrhosis
Manuscript Source Unsolicited Manuscript
All Author List Maria Teresa Arias-Loste, Maria Teresa García-Unzueta, Susana Llerena, Paula Iruzubieta, Angela Puente, Joaquín Cabezas, Carmen Alonso, Antonio Cuadrado, José Antonio Amado, Javier Crespo and Emilio Fábrega
Funding Agency and Grant Number
Corresponding author Emilio Fábrega, PhD, MD, Gastro¬enterology and Hepatology Unit, Marqués de Valdecilla University Hospital, Instituto de Investigación Sanitaria Valdecilla, Avenida Valdecilla s/n, 39008 Santander, Cantabria, Spain. digfge@humv.es
Keywords Liver cirrhosis; Betatrophin; Insulin resistance; Betatrophin liver; Betatrophin insulin
Core Tip Recently, Douglas A. Melton’s group from Harvard University reported the identification of betatrophin, a circulating protein secreted from the liver under insulin resistant states. Insulin resistance is common in patients with cirrhosis. In our study we confirm that betatrophin is increased in patients with liver cirrhosis, and the increase in plasma betatrophin levels is related to the severity of cirrhosis, and the emergence of insulin resistance. These preliminary results show that betatrophin may contribute to counteract, at least in part, insulin resistance in patients with cirrhosis.
Publish Date 2015-09-28 18:06
Citation Arias-Loste MT, García-Unzueta MT, Llerena S, Iruzubieta P, Puente A, Cabezas J, Alonso C, Cuadrado A, Amado JA, Crespo J, Fábrega E. Plasma betatrophin levels in patients with liver cirrhosis. World J Gastroenterol 2015; 21(37): 10662-10668
Url http://www.wjgnet.com/1007-9327/full/v21/i37/10662.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i37.10662
Full Article (PDF) WJG-21-10662.pdf
Full Article (Word) WJG-21-10662.doc
Manuscript File 17212-Review.docx
Answering Reviewers 17212-Answering reviewers.pdf
Audio Core Tip 17212-Audio core tip.wav
Biostatistics Review Certificate 17212-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 17212-Conflict-of-interest statement.pdf
Copyright License Agreement 17212-Copyright assignment.pdf
Data Sharing Statement 17212-Data sharing statement.pdf
Institutional Review Board Approval Form or Document 17212-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 17212-Language certificate.pdf
Peer-review Report 17212-Peer-review(s).pdf
Scientific Misconduct Check 17212-Scientific misconduct check.pdf
Scientific Editor Work List 17212-Scientific editor work list.pdf