Publication Name	World Journal of Cardiology
Manuscript ID	17214
Country	Italy

Received	2015-02-25 10:22
Peer-Review Started	2015-02-26 10:52
To Make the First Decision	2015-05-14 16:43
Return for Revision	2015-05-18 20:28
Revised	2015-06-11 00:00
Second Decision	2015-09-14 09:59
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-28 17:38
Articles in Press	2015-09-28 17:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-12 16:31
Publish the Manuscript Online	2015-11-03 08:25

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Review
Article Title	Lipoprotein-associated phospholipase A2 prognostic role in atherosclerotic complications
Manuscript Source	Invited Manuscript
All Author List	Giuseppe Maiolino, Valeria Bisogni, Giacomo Rossitto and Gian Paolo Rossi
Funding Agency and Grant Number	Funding Agency Grant Number FOundation for Advanced Research in Hypertension and Cardiovascular diseases
Corresponding Author	Gian Paolo Rossi, MD, FACC, FAHA, Professor, Department of Medicine - DIMED, Hypertension Clinic, University of Padua, Via Giustiniani, 2, 35128 Padova, Italy. gianpaolo.rossi@unipd.it
Key Words	Lipoprotein-associated phospholipase A2; Atherosclerosis; Coronary artery disease; Myocardial infarction; Prognosis
Core Tip	Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a promising new marker of atherosclerotic plaque destabilization, which plays a key role in the metabolism of pro-inflammatory phospholipids and in the generation of pro-atherogenic metabolites. This review focuses on the experimental and clinical studies supporting use of Lp-PLA2 for predicting cardiovascular events considering not only Lp-PLA2 activity and mass, but also Lp-PLA2 gene variations. Based on current evidences the major scientific societies have included Lp-PLA2 activity measurement in their guidelines among the biomarkers that are useful in risk stratification of adult asymptomatic patients at intermediate cardiovascular risk.
Publish Date	2015-11-03 08:25
Citation	Maiolino G, Bisogni V, Rossitto G, Rossi GP. Lipoprotein-associated phospholipase A2 prognostic role in atherosclerotic complications. World J Cardiol 2015; 7(10): 609-620
URL	http://www.wjgnet.com/1949-8462/full/v7/i10/609.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i10.609

Full Article (PDF)	WJC-7-609.pdf
Full Article (Word)	WJC-7-609.doc
Manuscript File	17214-Review.doc
Answering Reviewers	17214-Answering reviewers.pdf
Audio Core Tip	17214-Audio core tip.aif
Conflict-of-Interest Disclosure Form	17214-Conflict-of-interest statement.pdf
Copyright License Agreement	17214-Copyright assignment.pdf
Peer-review Report	17214-Peer-review(s).pdf
Scientific Misconduct Check	17214-Scientific misconduct check.pdf
Scientific Editor Work List	17214-Scientific editor work list.pdf