Publication Name	World Journal of Gastroenterology
Manuscript ID	1723
Country	China

Received	2012-12-31 08:49
Peer-Review Started	2012-12-31 11:31
First Decision by Editorial Office Director
Return for Revision	2013-02-17 11:23
Revised	2013-02-21 19:23
Publication Fee Transferred
Second Decision by Editor	2013-04-03 15:27
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-04-04 04:13
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-04 17:40
Publish the Manuscript Online	2013-06-20 16:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Bone-marrow mesenchymal stem cells reduce rat intestinal ischemia-reperfusion injury, ZO-1 downregulation and tight junction disruption via a TNF-α-regulated mechanism
Manuscript Source	Invited Manuscript
All Author List	Zhong-Yang Shen, Jing Zhang, Hong-Li Song and Wei-Ping Zheng
Funding Agency and Grant Number	Funding Agency Grant Number Natural Science Foundation of China 81270528 Natural Science Foundation of Tianjin 08JCYBJC08400 Natural Science Foundation of Tianjin 11JCZDJC27800 Natural Science Foundation of Tianjin 12JCZDJC25200 Technology Foundation of Health Bureau in Tianjin 2011KY11
Corresponding Author	Hong-Li Song, MD, PhD, Professor of Medicine, Department of Organ Transplantation, Tianjin First Central Hospital, No. 24 Fukang Road, Nankai District, Tianjin 300192, China. hlsong26@163.com
Key Words	Bone marrow mesenchymal stem cells; Zona occludens 1; Ischemia-reperfusion injury; Intestinal mucosa; Tumor necrosis factor-α
Core Tip	Intestinal ischemia/reperfusion (I/R) injury is clinically important. Bone-marrow mesenchymal stem cells (BM MSCs) can protect against I/R injury; however, the mechanism is unclear. This study demonstrates that submucosal infusion of BM MSCs decreased intestinal permeability and preserved intestinal mechanical barrier function after I/R injury in rats, via a mechanism linked to reduced serum tumor necrosis factor (TNF)-α levels and increased expression of the intestinal tight junction protein zona occludens 1. Altered serum TNF-α levels play an important role in the ability of BM MSCs to protect against intestinal I/R injury.
Publish Date	2013-06-20 16:34
Citation	Shen ZY, Zhang J, Song HL, Zheng WP. Bone-marrow mesenchymal stem cells reduce rat intestinal ischemia-reperfusion injury, ZO-1 downregulation and tight junction disruption via a TNF-α-regulated mechanism. World J Gastroenterol 2013; 19(23): 3583-3595
URL	http://www.wjgnet.com/1007-9327/full/v19/i23/3583.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i23.3583

Full Article (PDF)	WJG-19-3583.pdf
Manuscript File	1723-Review.doc
Answering Reviewers	1723-Answering Reviewers.doc
Copyright License Agreement	1723-Copyright Assignment.pdf
Non-Native Speakers of English Editing Certificate	1723-Language certificate.pdf
Peer-review Report	1723-Peer review(s).pdf
Scientific Editor Work List	1723-Scientific editor work list.doc