Publication Name	World Journal of Hepatology
Manuscript ID	17249
Country	Greece

Received	2015-02-26 09:12
Peer-Review Started	2015-02-26 18:22
To Make the First Decision	2015-05-14 16:43
Return for Revision	2015-05-18 20:34
Revised	2015-06-07 16:39
Second Decision	2015-06-24 08:21
Accepted by Journal Editor-in-Chief	2015-06-25 15:59
Accepted by Executive Editor-in-Chief	2015-07-02 16:15
Articles in Press	2015-07-02 16:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-28 20:31
Publish the Manuscript Online	2015-08-21 13:37

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Intestinal barrier dysfunction in cirrhosis: Current concepts in pathophysiology and clinical implications
Manuscript Source	Invited Manuscript
All Author List	Georgios I Tsiaoussis, Stelios F Assimakopoulos, Athanassios C Tsamandas, Christos K Triantos and Konstantinos C Thomopoulos
Funding Agency and Grant Number
Corresponding Author	Georgios I Tsiaoussis, MD, Department of Gastroenterology and Hepatology, University Hospital of Patras, Rio Patras, CP 26504 Patras, Greece. tsiaoussisgeorgios@yahoo.com
Key Words	Cirrhosis; Intestinal barrier; Tight junction; Bacterial translocation; Intestinal bacterial overgrowth
Core Tip	Intestinal barrier function is impaired in patients with cirrhosis and this derangement seems to be associated with liver disease severity. This phenomenon is multifactorial and the exact pathophysiological mechanisms which are implicated in this deterioration have not been fully elucidated yet. The disruption of intestinal barrier integrity and the subsequent increased intestinal permeability in cirrhotic patients promote bacterial translocation and play a major role in the development of severe clinical complications affecting natural history of liver disease and patients’ survival.
Publish Date	2015-08-21 13:37
Citation	Tsiaoussis GI, Assimakopoulos SF, Tsamandas AC, Triantos CK, Thomopoulos KC. Intestinal barrier dysfunction in cirrhosis: Current concepts in pathophysiology and clinical implications. World J Hepatol 2015; 7(17): 2058-2068
URL	http://www.wjgnet.com/1948-5182/full/v7/i17/2058.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i17.2058

Full Article (PDF)	WJH-7-2058.pdf
Full Article (Word)	WJH-7-2058.doc
Manuscript File	17249-Review.doc
Answering Reviewers	17249-Answering reviewers.pdf
Audio Core Tip	17249-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17249-Conflict-of-interest statement.pdf
Copyright License Agreement	17249-Copyright assignment.pdf
Supplementary Material	Supplementary_Material_20150225232404.docx
Peer-review Report	17249-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17249-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17249-Scientific misconduct check.pdf
Scientific Editor Work List	17249-Scientific editor work list.pdf