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8/21/2015 1:38:00 PM | Browse: 589 | Download: 902
Publication Name World Journal of Hepatology
Manuscript ID 17249
Country/Territory Greece
Received
2015-02-26 09:12
Peer-Review Started
2015-02-26 18:22
To Make the First Decision
2015-05-14 16:43
Return for Revision
2015-05-18 20:34
Revised
2015-06-07 16:39
Second Decision
2015-06-24 08:21
Accepted by Journal Editor-in-Chief
2015-06-25 15:59
Accepted by Company Editor-in-Chief
2015-07-02 16:15
Articles in Press
2015-07-02 16:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-07-28 20:31
Publish the Manuscript Online
2015-08-21 13:37
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Editorial
Article Title Intestinal barrier dysfunction in cirrhosis: Current concepts in pathophysiology and clinical implications
Manuscript Source Invited Manuscript
All Author List Georgios I Tsiaoussis, Stelios F Assimakopoulos, Athanassios C Tsamandas, Christos K Triantos and Konstantinos C Thomopoulos
Funding Agency and Grant Number
Corresponding author Georgios I Tsiaoussis, MD, Department of Gastroenterology and Hepatology, University Hospital of Patras, Rio Patras, CP 26504 Patras, Greece. tsiaoussisgeorgios@yahoo.com
Keywords Cirrhosis; Intestinal barrier; Tight junction; Bacterial translocation; Intestinal bacterial overgrowth
Core Tip Intestinal barrier function is impaired in patients with cirrhosis and this derangement seems to be associated with liver disease severity. This phenomenon is multifactorial and the exact pathophysiological mechanisms which are implicated in this deterioration have not been fully elucidated yet. The disruption of intestinal barrier integrity and the subsequent increased intestinal permeability in cirrhotic patients promote bacterial translocation and play a major role in the development of severe clinical complications affecting natural history of liver disease and patients’ survival.
Publish Date 2015-08-21 13:37
Citation Tsiaoussis GI, Assimakopoulos SF, Tsamandas AC, Triantos CK, Thomopoulos KC. Intestinal barrier dysfunction in cirrhosis: Current concepts in pathophysiology and clinical implications. World J Hepatol 2015; 7(17): 2058-2068
Url http://www.wjgnet.com/1948-5182/full/v7/i17/2058.htm
DOI http://dx.doi.org/10.4254/wjh.v7.i17.2058
Full Article (PDF) WJH-7-2058.pdf
Full Article (Word) WJH-7-2058.doc
Manuscript File 17249-Review.doc
Answering Reviewers 17249-Answering reviewers.pdf
Audio Core Tip 17249-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 17249-Conflict-of-interest statement.pdf
Copyright License Agreement 17249-Copyright assignment.pdf
Supplementary Material Supplementary_Material_20150225232404.docx
Peer-review Report 17249-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 17249-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 17249-Scientific misconduct check.pdf
Scientific Editor Work List 17249-Scientific editor work list.pdf