Publication Name	World Journal of Gastroenterology
Manuscript ID	17262
Country	China

Received	2015-02-27 09:15
Peer-Review Started	2015-02-27 17:17
To Make the First Decision	2015-03-26 17:54
Return for Revision	2015-03-30 13:53
Revised	2015-04-11 17:26
Second Decision	2015-07-02 21:51
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-07-03 17:23
Articles in Press	2015-07-03 17:23
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-07-21 21:55
Typeset the Manuscript	2015-08-20 14:45
Publish the Manuscript Online	2015-09-14 16:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	MiR-9a-5p regulates proliferation and migration of hepatic stellate cells under pressure through inhibition of Sirt1
Manuscript Source	Unsolicited Manuscript
All Author List	Feng Qi, Jiang-Feng Hu, Bao-Hai Liu, Chao-Qun Wu, Hong-Yu Yu, Ding-Kang Yao and Liang Zhu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 11272342/A0205
Corresponding Author	Liang Zhu, Professor, Department of Gastroenterology, Changzheng Hospital, the Second Military Medical University, No. 415 Fengyang Road, Shanghai 200003, China. zhuliangcz@126.com
Key Words	MicroRNA; miR-9a-5p; Sirt1; Pressure; Hepatic stellate cells
Core Tip	Portal hypertension is a syndrome as the main characteristics of the portal system hemodynamics change. Hepatic stellate cell (HSC) activation is the key factor of promoting the development of the occurrence of liver cirrhosis and portal hypertension. We determined the levels of miR-9a-5p in HSCs under pressure. We found that higher levels of miR-9a-5p, which targeted Sirt1, were expressed in vivo. The restored expression of miR-9a-5p and Sirt1 could significantly suppress the proliferation, migration and activation of HSCs.
Publish Date	2015-09-14 16:54
Citation	Qi F, Hu JF, Liu BH, Wu CQ, Yu HY, Yao DK, Zhu L. MiR-9a-5p regulates proliferation and migration of hepatic stellate cells under pressure through inhibition of Sirt1. World J Gastroenterol 2015; 21(34): 9900-9915
URL	http://www.wjgnet.com/1007-9327/full/v21/i34/9900.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i34.9900

Full Article (PDF)	WJG-21-9900.pdf
Full Article (Word)	WJG-21-9900.doc
Manuscript File	17262-Review.docx
Answering Reviewers	17262-Answering reviewers.pdf
Audio Core Tip	17262-Audio core tip.mp3
Biostatistics Review Certificate	17262-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	17262-Conflict-of-interest statement.pdf
Copyright License Agreement	17262-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	17262-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate	17262-Language certificate.pdf
Supplementary Material	17262-Supplementary material.xls
Peer-review Report	17262-Peer-review(s).pdf
Scientific Misconduct Check	17262-Scientific misconduct check.pdf
Scientific Editor Work List	17262-Scientific editor work list.pdf