Publication Name	World Journal of Gastroenterology
Manuscript ID	1727
Country	Australia

Received	2013-01-01 20:12
Peer-Review Started	2013-01-01 21:04
To Make the First Decision	2013-01-09 16:05
Return for Revision	2013-01-11 11:04
Revised	2013-02-13 07:15
Second Decision	2013-03-28 17:23
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-03-29 11:50
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor	2013-06-30 23:07
Typeset the Manuscript	2013-07-19 08:42
Publish the Manuscript Online	2013-07-29 11:18

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Resistin mediates the hepatic stellate cell phenotype
Manuscript Source	Invited Manuscript
All Author List	Zhi-Xia Dong, Lin Su, Joanne Brymora, Claire Bird, Qing Xie, Jacob George and Jian-Hua Wang
Funding Agency and Grant Number
Corresponding Author	Jian-Hua Wang, MD, PhD, Storr Liver Unit, Westmead Millennium Institute and Westmead Hospital, University of Sydney, Westmead, NSW 2145, Australia. jianhua.wang@sydney.edu.au
Key Words	Resistin; Hepatic stellate cell; Kupffer cell; Liver fibrosis; Monocyte chemotactic protein-1
Core Tip	Resistin activated hepatic stellate cells (HSCs) phospho-MAPK/p38, and p38 inhibition diminished interleukin 6 (IL-6) and monocyte chemotactic protein-1 (MCP-1) expression. Furthermore, resistin facilitated HSC proliferation and migration, but decreased apoptosis which was via an IL-6 and MCP-1 mechanism. Finally, resistin-induced transforming growth factor β1 from Kupffer cells enhanced HSC collagen I expression. Resistin directly and indirectly modulates HSC behavior towards a more pro-fibrogenic phenotype.
Publish Date	2013-07-29 11:18
Citation	Dong ZX, Su L, Brymora J, Bird C, Xie Q, George J, Wang JH. Resistin mediates the hepatic stellate cell phenotype. World J Gastroenterol 2013; 19(28): 4475-4485
URL	http://www.wjgnet.com/1007-9327/full/v19/i28/4475.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i28.4475

Full Article (PDF)	WJG-19-4475.pdf
Manuscript File	1727-Review.doc
Answering Reviewers	1727-Answering reviewers.doc
Biostatistics Review Certificate	WJG 24-12-12 resistin MS (1).pdf
Copyright License Agreement	1727-Copyright assignment.docx
Institutional Review Board Approval Form or Document	4117 ethics approval.pdf
Non-Native Speakers of English Editing Certificate	1727-Language cetificate.doc
Peer-review Report	1727-Peer review.pdf
Scientific Editor Work List	1727-Scientific editor work list.doc