Publication Name	World Journal of Gastroenterology
Manuscript ID	17297
Country	Italy

Received	2015-02-28 10:06
Peer-Review Started	2015-02-28 14:45
To Make the First Decision	2015-04-13 15:44
Return for Revision	2015-04-20 16:50
Revised	2015-04-28 22:21
Second Decision	2015-06-26 09:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-07-03 16:57
Articles in Press	2015-07-03 16:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-29 15:46
Publish the Manuscript Online	2015-08-17 11:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Rossella Farra, Mario Grassi, Gabriele Grassi and Barbara Dapas
Funding Agency and Grant Number	Funding Agency Grant Number Fondazione Cassa di Risparmio of Trieste Fondazione Benefica Kathleen Foreman Casali of Trieste “Beneficentia Stiftung” of Vaduz Liechtenstein Italian Minister of Instruction, University and Research, PRIN 2010-11 20109PLMH2 (in part)
Corresponding Author	Gabriele Grassi, MD, PhD, Department of Life Sciences, University of Trieste, Cattinara Hospital, Strada di Fiume 447, 34100 Trieste, Italy. ggrassi@units.it
Key Words	Small interfering RNA; Micro interfering RNA; Delivery; Hepatocellular carcinoma; Therapeutic potential
Core Tip	Available therapeutic approaches for hepatocellular carcinoma (HCC) are poorly effective, especially for the advanced forms of the disease. In the last year, short double stranded RNA molecules termed small interfering RNAs (siRNAs) and micro interfering RNAs (miRNA), emerged as interesting molecules with potential therapeutic value for HCC. The practical use of these molecules is however limited by the identification of optimal molecular targets and especially by the lack of effective and targeted HCC delivery systems. Here we focus our discussion on the most recent advances in the identification of siRNAs/miRNAs molecular targets and on the development of suitable siRNA/miRNAs delivery systems.
Publish Date	2015-08-17 11:15
Citation	Farra R, Grassi M, Grassi G, Dapas B. Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma. World J Gastroenterol 2015; 21(30): 8994-9001
URL	http://www.wjgnet.com/1007-9327/full/v21/i30/8994.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i30.8994

Full Article (PDF)	WJG-21-8994.pdf
Full Article (Word)	WJG-21-8994.doc
Manuscript File	17297-Review.docx
Answering Reviewers	17297-Answering reviewers.pdf
Audio Core Tip	17297-Audio core tip.wav
Conflict-of-Interest Disclosure Form	17297-Conflict-of-interest statement.pdf
Copyright License Agreement	17297-Copyright assignment.pdf
Peer-review Report	17297-Peer-review(s).pdf
Scientific Misconduct Check	17297-Scientific misconduct check.pdf
Scientific Editor Work List	17297-Scientific editor work list.pdf