Publication Name	World Journal of Gastroenterology
Manuscript ID	17335
Country	South Korea

Received	2015-03-01 18:06
Peer-Review Started	2015-03-02 14:48
To Make the First Decision	2015-03-26 17:23
Return for Revision	2015-03-30 13:56
Revised	2015-04-11 20:16
Second Decision	2015-06-09 12:04
Accepted by Journal Editor-in-Chief	2015-06-09 15:26
Accepted by Company Editor-in-Chief	2015-06-16 11:10
Articles in Press	2015-06-16 11:10
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-07-15 11:27
Typeset the Manuscript	2015-08-20 17:40
Publish the Manuscript Online	2015-09-07 16:31

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Annexin A10 expression in colorectal cancers with emphasis on the serrated neoplasia pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Jeong Mo Bae, Jung Ho Kim, Ye-Young Rhee, Nam-Yun Cho, Tae-You Kim and Gyeong Hoon Kang
Funding Agency and Grant Number	Funding Agency Grant Number Basic Science Research Program through the National Research Foundation 2013R1A1A2059080 Korean Health Technology R&D Project, Ministry of Health & Welfare HI13C1804 Priority Research Centers Program through the NRF funded by the Ministry of Education, Science and Technology 2009-0093820 NRF grant funded by the Ministry of Science, ICT, and Future planning 2011-0030049 Korea Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea HI14C1277
Corresponding Author	Gyeong Hoon Kang, MD, Professor, Department of Pathology, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-799, South Korea. ghkang@snu.ac.kr
Key Words	Annexin A10; Serrated neoplasia pathway; CpG island methylator phenotype; Colorectal cancer; BRAF mutation
Core Tip	Annexin A10 is considered a surrogate immu?nohistochemical marker for sessile serrated adenomas/polyps. We validated the utility of Annexin A10 as a surrogate marker of the serrated neoplasia pathway in invasive colorectal cancers (CRCs). Annexin A10 expression was associated with female sex, proximal location, ulcerative gross type, advanced TNM stage, serration and mucin production. CRCs with Annexin A10 expression were associated with CpG island methylator phenotype, microsatellite instability and BRAF mutation. In stage-specific survival analysis, Annexin A10 expression was associated with poor clinical outcome in stage Ⅳ CRCs. Annexin A10 can be used a supportive surrogate marker of the serrated neoplasia pathway.
Publish Date	2015-09-07 16:31
Citation	Bae JM, Kim JH, Rhee YY, Cho NY, Kim TY, Kang GH. Annexin A10 expression in colorectal cancers with emphasis on the serrated neoplasia pathway. World J Gastroenterol 2015; 21(33): 9749-9757
URL	http://www.wjgnet.com/1007-9327/full/v21/i33/9749.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i33.9749

Full Article (PDF)	WJG-21-9749.pdf
Full Article (Word)	WJG-21-9749.doc
Manuscript File	17335-Review.doc
Answering Reviewers	17335-Answering reviewers.pdf
Audio Core Tip	17335-Audio core tip.mp3
Biostatistics Review Certificate	17335-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	17335-Conflict-of-interest statement.pdf
Copyright License Agreement	17335-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	17335-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	17335-Language certificate.pdf
Peer-review Report	17335-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17335-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17335-Scientific misconduct check.pdf
Scientific Editor Work List	17335-Scientific editor work list.pdf