Publication Name	World Journal of Gastroenterology
Manuscript ID	17359
Country	Poland

Received	2015-03-03 08:02
Peer-Review Started	2015-03-04 19:19
To Make the First Decision	2015-05-18 12:33
Return for Revision	2015-05-19 15:59
Revised	2015-05-28 21:38
Second Decision	2015-08-06 21:11
Accepted by Journal Editor-in-Chief	2015-08-07 12:11
Accepted by Company Editor-in-Chief	2015-08-31 13:24
Articles in Press	2015-08-31 13:24
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-07 11:15
Publish the Manuscript Online	2015-09-28 18:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Brain-gut-microbiota axis in Parkinson's disease
Manuscript Source	Invited Manuscript
All Author List	Agata Mulak and Bruno Bonaz
Funding Agency and Grant Number
Corresponding Author	Agata Mulak, MD, PhD, Department of Gastroenterology and Hepatology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland. agata.mulak@wp.pl
Key Words	Brain-gut-microbiota axis; Enteric nervous system; Gastrointestinal dysfunction; Gut microbiota; Parkinson’s disease
Core Tip	Parkinson’s disease (PD) is characterized by alpha-synucleinopathy affecting all levels of the brain-gut axis. Both clinical and neuropathological evidences indicate that neurodegenerative changes in PD are accompanied by gastrointestinal symptoms that may precede or follow the central nervous system impairment. Dysregulation of the brain-gut-microbiota axis may significantly contribute to the pathogenesis of PD. The gut seems to play a critical role in the pathophysiology of PD representing a rout of entry for a putative environmental factor to initiate the pathological process. The close relationship between gut dysbiosis, intestinal permeability and neurological dysfunction suggests that the gut microbiota modification may provide a promising therapeutic option in PD.
Publish Date	2015-09-28 18:06
Citation	Mulak A, Bonaz B. Brain-gut-microbiota axis in Parkinson’s disease. World J Gastroenterol 2015; 21(37): 10609-10620
URL	http://www.wjgnet.com/1007-9327/full/v21/i37/10609.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i37.10609

Full Article (PDF)	WJG-21-10609.pdf
Full Article (Word)	WJG-21-10609.doc
Manuscript File	17359-Review.doc
Answering Reviewers	17359-Answering reviewers.pdf
Audio Core Tip	17359-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17359-Conflict-of-interest statement.pdf
Copyright License Agreement	17359-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	17359-Language certificate.pdf
Peer-review Report	17359-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17359-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17359-Scientific misconduct check.pdf
Scientific Editor Work List	17359-Scientific editor work list.pdf