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Articles Published Processes
9/14/2015 4:53:00 PM | Browse: 912 | Download: 1510
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Received |
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2015-03-06 08:38 |
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Peer-Review Started |
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2015-03-07 16:23 |
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To Make the First Decision |
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2015-04-24 19:21 |
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Return for Revision |
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2015-04-29 16:55 |
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Revised |
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2015-05-12 17:36 |
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Second Decision |
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2015-07-17 17:07 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-07-18 11:12 |
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Articles in Press |
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2015-07-18 11:12 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-08-04 20:58 |
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Typeset the Manuscript |
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2015-08-26 18:28 |
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Publish the Manuscript Online |
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2015-09-14 16:54 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
β-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jun-Song Liu, Xiang-Ming Che, Shuai Chang, Guang-Lin Qiu, Shi-Cai He, Lin Fan, Wei Zhao, Zheng-Liang Zhang and Shu-Feng Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Nature Science Foundation of China |
81172357 |
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| Corresponding Author |
Shu-Feng Wang, MD, Department of General Surgery, First Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Yanta West Road 277, Xi’an 710061, Shaanxi Province, China. dawn@mail.xjtu.edu.cn |
| Key Words |
β-elemene; Radiosensitivity; Gastric cancer cells; Clonogenic survival; Apoptosis; p21-activated protein kinase 1 |
| Core Tip |
In this study, we explore the potential of β-elemene, a novel anti-cancer drug isolated from the Chinese traditional herb Curcuma wenyujin, as a radiosensitizer for gastric cancer cells, and the underlying mechanisms. β-elemene pretreatment decreased clonogenic survival and increased apoptosis in response to ionizing radiation in SGC7901 and MKN45 gastric cancer cell lines. This is the first demonstration that β-elemene enhances radiosensitivity of gastric cancer cells. The underlying mechanism involves inhibition of p21-activated protein kinase 1 (Pak1) signaling. We also provide direct evidence for targeting Pak1 signaling as a means to sensitize cancer cells to ionizing radiation. |
| Publish Date |
2015-09-14 16:54 |
| Citation |
Liu JS, Che XM, Chang S, Qiu GL, He SC, Fan L, Zhao W, Zhang ZL, Wang SF. β-elemene enhances the radiosensitivity of gastric cancer cells by inhibiting Pak1 activation. World J Gastroenterol 2015; 21(34): 9945-9956 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i34/9945.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i34.9945 |
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