Publication Name	World Journal of Biological Chemistry
Manuscript ID	17442
Country	United States

Received	2015-03-07 16:23
Peer-Review Started	2015-03-07 21:13
To Make the First Decision	2015-04-10 17:24
Return for Revision	2015-04-15 11:58
Revised	2015-04-16 23:23
Second Decision	2015-04-26 20:19
Accepted by Journal Editor-in-Chief	2015-04-27 00:41
Accepted by Company Editor-in-Chief	2015-05-28 18:21
Articles in Press	2015-05-28 18:21
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-08 17:30
Publish the Manuscript Online	2015-08-26 11:07

ISSN	1949-8454 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Editorial
Article Title	DNA damage responses in cancer stem cells: Implications for cancer therapeutic strategies
Manuscript Source	Invited Manuscript
All Author List	Qi-En Wang
Funding Agency and Grant Number	Funding Agency Grant Number NCI R01 CA151248
Corresponding Author	Qi-En Wang, PhD, Division of Radiobiology, Department of Radiology, the Ohio State University, Wexner Medical Center, Room 1014, 460 W. 12th Ave., Columbus, OH 43210, United States. qi-en.wang@osumc.edu
Key Words	Cancer stem cell; DNA damage response; DNA repair; Cancer therapy
Core Tip	Cancer stem cells (CSCs) are thought to be at the root of cancer recurrence and therapeutic resistance. Eradication of CSCs could be a key to successful cancer therapeutics. Studies have shown that CSCs possess highly efficient ability to process DNA damage. This elevated DNA damage response (DDR) is believed to be responsible for the resistance to DNA damaging agents. Thus, targeting enhanced DDR in CSCs may be a promising strategy to facilitate elimination of these highly tumorigenic cells by conventional therapies.
Publish Date	2015-08-26 11:07
Citation	Wang QE. DNA damage responses in cancer stem cells: Implications for cancer therapeutic strategies. World J Biol Chem 2015; 6(3): 57-64
URL	http://www.wjgnet.com/1949-8454/full/v6/i3/57.htm
DOI	http://dx.doi.org/10.4331/wjbc.v6.i3.57

Full Article (PDF)	WJBC-6-57.pdf
Full Article (Word)	WJBC-6-57.doc
Manuscript File	17442-Review.docx
Answering Reviewers	17442-Answering reviewers.pdf
Audio Core Tip	17442-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17442-Conflict-of-interest statement.pdf
Copyright License Agreement	17442-Copyright assignment.pdf
Peer-review Report	17442-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17442-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17442-Scientific misconduct check.pdf
Scientific Editor Work List	17442-Scientific editor work list.pdf