Publication Name	World Journal of Gastroenterology
Manuscript ID	17444
Country	Egypt

Received	2015-03-07 16:26
Peer-Review Started	2015-03-11 17:06
To Make the First Decision	2015-04-13 16:46
Return for Revision	2015-04-16 14:11
Revised	2015-05-16 05:32
Second Decision	2015-09-28 16:05
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-30 10:07
Articles in Press	2015-09-30 10:07
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-10-27 04:53
Typeset the Manuscript	2015-12-04 17:05
Publish the Manuscript Online	2016-01-06 16:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Review
Article Title	Status of hepatitis C virus vaccination: Recent update
Manuscript Source	Invited Manuscript
All Author List	Kouka Saadeldin Abdelwahab and Zeinab Nabil Ahmed Said
Funding Agency and Grant Number
Corresponding Author	Zeinab Nabil Ahmed Said, Professor, Department of Microbiology and Immunology, Faculty of Medicine (for girls), Al-Azhar University, Nasr City, 8, Ossama Ibn Monkez Street, Heliopolis, Cairo 11435, Egypt. znabil58@yahoo.com
Key Words	Hepatitis C; Viral envelope glycoproteins; Immune response; Hepatitis C virus vaccine; Clinical trials
Core Tip	Hepatitis C virus (HCV) is a major global public health problem. Chronic HCV infection affected around 130-150 million of the world’s population. The current treatment is expensive, showed some restrictions and is not efficient for all patients. No licensed vaccine is available for clinical use, however, researches on developing a preventive and therapeutic safe vaccine, are evolving. This review gives an overview of HCV structure, immune response and viral evasion mechanisms. It also evaluates the available preventive and therapeutic vaccines that induce innate, antibody-mediated immune response, cell-mediated immune response and interferon, and highlights the progress in recent HCV vaccination studies either in preclinical or clinical phases.
Publish Date	2016-01-06 16:13
Citation	Abdelwahab KS, Ahmed Said ZN. Status of hepatitis C virus vaccination: Recent update. World J Gastroenterol 2016; 22(2): 862-873
URL	http://www.wjgnet.com/1007-9327/full/v22/i2/862.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i2.862

Full Article (PDF)	WJG-22-862.pdf
Full Article (Word)	WJG-22-862.doc
Manuscript File	17444-Review.docx
Answering Reviewers	17444-Answering reviewers.pdf
Audio Core Tip	17444-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17444-Conflict-of-interest statement.pdf
Copyright License Agreement	17444-Copyright assignment.pdf
Supplementary Material	Supplementary_Material_20150307030451.docx
Peer-review Report	17444-Peer-review(s).pdf
Scientific Misconduct Check	17444-Scientific misconduct check.pdf
Scientific Editor Work List	17444-Scientific editor work list.pdf