Publication Name	World Journal of Gastroenterology
Manuscript ID	17446
Country	Poland

Received	2015-03-07 16:30
Peer-Review Started	2015-03-11 17:18
First Decision by Editorial Office Director
Return for Revision	2015-04-29 17:31
Revised	2015-05-14 05:49
Publication Fee Transferred
Second Decision by Editor	2015-06-10 09:18
Second Decision by Editor-in-Chief	2015-06-10 12:14
Final Decision by Editorial Office Director	2015-06-16 11:36
Articles in Press	2015-06-16 11:36
Edit the Manuscript by Language Editor	2015-09-01 00:28
Typeset the Manuscript	2015-09-23 08:20
Publish the Manuscript Online	2015-09-28 18:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Histological healing after infliximab induction therapy in children with ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Anna Wiernicka, Sylwia Szymanska, Joanna Cielecka-Kuszyk, Maciej Dadalski and Jaroslaw Kierkus
Funding Agency and Grant Number	Funding Agency Grant Number Children’s Memorial Health Institute Internal Grant S129/2013 (in part)
Corresponding Author	Dr. Jaroslaw Kierkus, Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children’s Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland. j.kierkus@czd.pl
Key Words	Ulcerative colitis; Endoscopy; Histopathology; Inflammation; Infliximab
Core Tip	The impact of infliximab induction therapy on histological healing in pediatric ulcerative colitis (UC) patients is unknown. The present study demonstrates that infliximab induction therapy had a positive influence on histological changes expressed by normal surface, crypt architecture, number of crypts, and lamina propria cellularity in 37.5% of UC patients. The treatment was effective in reducing intestinal inflammation as assessed by the Geboes Index (62.5% of patients). Furthermore, it was shown that there was no significant correlation of histological healing with endoscopic remission and clinical remission.
Publish Date	2015-09-28 18:06
Citation	Wiernicka A, Szymanska S, Cielecka-Kuszyk J, Dadalski M, Kierkus J. Histological healing after infliximab induction therapy in children with ulcerative colitis. World J Gastroenterol 2015; 21(37): 10654-10661
URL	http://www.wjgnet.com/1007-9327/full/v21/i37/10654.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i37.10654

Full Article (PDF)	WJG-21-10654.pdf
Full Article (Word)	WJG-21-10654.doc
Manuscript File	17446-Review.doc
Answering Reviewers	17446-Answering reviewers.pdf
Audio Core Tip	17446-Audio core tip.wma
Conflict-of-Interest Disclosure Form	17446-Conflict-of-Interest Statement.pdf
Copyright License Agreement	17446-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	17446-Institutional review board statement.pdf
Peer-review Report	17446-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17446-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17446-Scientific misconduct check.pdf
Scientific Editor Work List	17446-Scientific editor work list.pdf