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9/28/2015 6:06:00 PM | Browse: 1024 | Download: 1674
Publication Name World Journal of Gastroenterology
Manuscript ID 17446
Country/Territory Poland
Received
2015-03-07 16:30
Peer-Review Started
2015-03-11 17:18
To Make the First Decision
2015-04-24 19:21
Return for Revision
2015-04-29 17:31
Revised
2015-05-14 05:49
Second Decision
2015-06-10 09:18
Accepted by Journal Editor-in-Chief
2015-06-10 12:14
Accepted by Company Editor-in-Chief
2015-06-16 11:36
Articles in Press
2015-06-16 11:36
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-09-01 00:28
Typeset the Manuscript
2015-09-23 08:20
Publish the Manuscript Online
2015-09-28 18:06
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Cohort Study
Article Title Histological healing after infliximab induction therapy in children with ulcerative colitis
Manuscript Source Unsolicited Manuscript
All Author List Anna Wiernicka, Sylwia Szymanska, Joanna Cielecka-Kuszyk, Maciej Dadalski and Jaroslaw Kierkus
Funding Agency and Grant Number
Funding Agency Grant Number
Children’s Memorial Health Institute Internal Grant S129/2013 (in part)
Corresponding Author Dr. Jaroslaw Kierkus, Department of Gastroenterology, Hepatology, Feeding Disorders and Pediatrics, The Children’s Memorial Health Institute, Al. Dzieci Polskich 20, 04-730 Warsaw, Poland. j.kierkus@czd.pl
Key Words Ulcerative colitis; Endoscopy; Histopathology; Inflammation; Infliximab
Core Tip The impact of infliximab induction therapy on histological healing in pediatric ulcerative colitis (UC) patients is unknown. The present study demonstrates that infliximab induction therapy had a positive influence on histological changes expressed by normal surface, crypt architecture, number of crypts, and lamina propria cellularity in 37.5% of UC patients. The treatment was effective in reducing intestinal inflammation as assessed by the Geboes Index (62.5% of patients). Furthermore, it was shown that there was no significant correlation of histological healing with endoscopic remission and clinical remission.
Publish Date 2015-09-28 18:06
Citation Wiernicka A, Szymanska S, Cielecka-Kuszyk J, Dadalski M, Kierkus J. Histological healing after infliximab induction therapy in children with ulcerative colitis. World J Gastroenterol 2015; 21(37): 10654-10661
URL http://www.wjgnet.com/1007-9327/full/v21/i37/10654.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i37.10654
Full Article (PDF) WJG-21-10654.pdf
Full Article (Word) WJG-21-10654.doc
Manuscript File 17446-Review.doc
Answering Reviewers 17446-Answering reviewers.pdf
Audio Core Tip 17446-Audio core tip.wma
Conflict-of-Interest Disclosure Form 17446-Conflict-of-Interest Statement.pdf
Copyright License Agreement 17446-Copyright assignment.pdf
Institutional Review Board Approval Form or Document 17446-Institutional review board statement.pdf
Peer-review Report 17446-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 17446-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 17446-Scientific misconduct check.pdf
Scientific Editor Work List 17446-Scientific editor work list.pdf