Publication Name	World Journal of Gastroenterology
Manuscript ID	17457
Country	China

Received	2015-03-08 14:40
Peer-Review Started	2015-03-11 18:41
First Decision by Editorial Office Director
Return for Revision	2015-04-29 18:13
Revised	2015-05-09 21:36
Publication Fee Transferred
Second Decision by Editor	2015-06-03 08:09
Second Decision by Editor-in-Chief	2015-06-03 17:23
Final Decision by Editorial Office Director	2015-06-10 16:30
Articles in Press	2015-06-10 16:30
Edit the Manuscript by Language Editor	2015-07-11 09:08
Typeset the Manuscript	2015-07-29 15:44
Publish the Manuscript Online	2015-08-17 11:15

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Research & Experimental Medicine
Manuscript Type	Basic Study
Article Title	Protective effect of Salvia miltiorrhiza and Carthamus tinctorius extract against lipopolysaccharide-induced liver injury
Manuscript Source	Unsolicited Manuscript
All Author List	Li-Na Gao, Kuo Yan, Yuan-Lu Cui, Guan-Wei Fan and Yue-Fei Wang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81173469 National Natural Science Foundation of China 81273891 Key New Drug Creation and Manufacturing Program 2012ZX09304007
Corresponding Author	Yuan-Lu Cui, Professor, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 88 YuQuan Road, Nankai District, Tianjin 300193, China. cuiyl@tju.edu.cn
Key Words	Salvia miltiorrhiza; Carthamus tinctorius; Apoptosis; Anti-inflammatory; Antioxidant; Acute liver injury
Core Tip	Salvia miltiorrhiza and Carthamus tinctorius extract [Danhong injection (DHI)] effectively protected against hepatic injury. DHI intervention significantly reduced alanine transferase, aspartate transaminase, total bilirubin, malondialdehyde, glutathione-S-transferase, tumour necrosis factor-α, interleukin-6, and caspase-3 levels in an lipopolysaccharide (LPS)-induced mouse model of acute liver injury. Moreover, DHI antagonised LPS-induced Bcl-2 and Bax expression and inhibited IκBα and nuclear factor-κB p65 phosphorylation. These findings suggest that Salvia miltiorrhiza and Carthamus tinctorius extract (such as DHI) acts as a multi-function protectant against acute hepatic injury in mice through its anti-inflammatory, anti-oxidative and anti-apoptotic activities.
Publish Date	2015-08-17 11:15
Citation	Gao LN, Yan K, Cui YL, Fan GW, Wang YF. Protective effect of Salvia miltiorrhiza and Carthamus tinctorius extract against lipopolysaccharide-induced liver injury. World J Gastroenterol 2015; 21(30): 9079-9092
URL	http://www.wjgnet.com/1007-9327/full/v21/i30/9079.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i30.9079

Full Article (PDF)	WJG-21-9079.pdf
Full Article (Word)	WJG-21-9079.doc
Manuscript File	17457-Review.doc
Answering Reviewers	17457-Answering reviewers.pdf
Audio Core Tip	17457-Audio core tip.mp3
Biostatistics Review Certificate	17457-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	17457-Conflict-of-interest statement.pdf
Copyright License Agreement	17457-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	17457-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	17457-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	17457-Language certificate.pdf
Peer-review Report	17457-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17457-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17457-Scientific misconduct check.pdf
Scientific Editor Work List	17457-Scientific editor work list.pdf