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8/17/2015 11:14:00 AM | Browse: 1008 | Download: 2241
Publication Name World Journal of Gastroenterology
Manuscript ID 17457
Country/Territory China
Received
2015-03-08 14:40
Peer-Review Started
2015-03-11 18:41
To Make the First Decision
2015-04-24 19:21
Return for Revision
2015-04-29 18:13
Revised
2015-05-09 21:36
Second Decision
2015-06-03 08:09
Accepted by Journal Editor-in-Chief
2015-06-03 17:23
Accepted by Company Editor-in-Chief
2015-06-10 16:30
Articles in Press
2015-06-10 16:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-07-11 09:08
Typeset the Manuscript
2015-07-29 15:44
Publish the Manuscript Online
2015-08-17 11:15
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Research & Experimental Medicine
Manuscript Type Basic Study
Article Title Protective effect of Salvia miltiorrhiza and Carthamus tinctorius extract against lipopolysaccharide-induced liver injury
Manuscript Source Unsolicited Manuscript
All Author List Li-Na Gao, Kuo Yan, Yuan-Lu Cui, Guan-Wei Fan and Yue-Fei Wang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81173469
National Natural Science Foundation of China 81273891
Key New Drug Creation and Manufacturing Program 2012ZX09304007
Corresponding Author Yuan-Lu Cui, Professor, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 88 YuQuan Road, Nankai District, Tianjin 300193, China. cuiyl@tju.edu.cn
Key Words Salvia miltiorrhiza; Carthamus tinctorius; Apoptosis; Anti-inflammatory; Antioxidant; Acute liver injury
Core Tip Salvia miltiorrhiza and Carthamus tinctorius extract [Danhong injection (DHI)] effectively protected against hepatic injury. DHI intervention significantly reduced alanine transferase, aspartate transaminase, total bilirubin, malondialdehyde, glutathione-S-transferase, tumour necrosis factor-α, interleukin-6, and caspase-3 levels in an lipopolysaccharide (LPS)-induced mouse model of acute liver injury. Moreover, DHI antagonised LPS-induced Bcl-2 and Bax expression and inhibited IκBα and nuclear factor-κB p65 phosphorylation. These findings suggest that Salvia miltiorrhiza and Carthamus tinctorius extract (such as DHI) acts as a multi-function protectant against acute hepatic injury in mice through its anti-inflammatory, anti-oxidative and anti-apoptotic activities.
Publish Date 2015-08-17 11:15
Citation Gao LN, Yan K, Cui YL, Fan GW, Wang YF. Protective effect of Salvia miltiorrhiza and Carthamus tinctorius extract against lipopolysaccharide-induced liver injury. World J Gastroenterol 2015; 21(30): 9079-9092
URL http://www.wjgnet.com/1007-9327/full/v21/i30/9079.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i30.9079
Full Article (PDF) WJG-21-9079.pdf
Full Article (Word) WJG-21-9079.doc
Manuscript File 17457-Review.doc
Answering Reviewers 17457-Answering reviewers.pdf
Audio Core Tip 17457-Audio core tip.mp3
Biostatistics Review Certificate 17457-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 17457-Conflict-of-interest statement.pdf
Copyright License Agreement 17457-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 17457-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 17457-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 17457-Language certificate.pdf
Peer-review Report 17457-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 17457-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 17457-Scientific misconduct check.pdf
Scientific Editor Work List 17457-Scientific editor work list.pdf