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Articles Published Processes
8/17/2015 11:14:00 AM | Browse: 1137 | Download: 2754
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Received |
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2015-03-08 14:40 |
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Peer-Review Started |
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2015-03-11 18:41 |
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To Make the First Decision |
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2015-04-24 19:21 |
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Return for Revision |
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2015-04-29 18:13 |
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Revised |
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2015-05-09 21:36 |
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Second Decision |
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2015-06-03 08:09 |
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Accepted by Journal Editor-in-Chief |
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2015-06-03 17:23 |
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Accepted by Executive Editor-in-Chief |
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2015-06-10 16:30 |
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Articles in Press |
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2015-06-10 16:30 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-07-11 09:08 |
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Typeset the Manuscript |
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2015-07-29 15:44 |
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Publish the Manuscript Online |
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2015-08-17 11:15 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Protective effect of Salvia miltiorrhiza and Carthamus tinctorius extract against lipopolysaccharide-induced liver injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Na Gao, Kuo Yan, Yuan-Lu Cui, Guan-Wei Fan and Yue-Fei Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81173469 |
| National Natural Science Foundation of China |
81273891 |
| Key New Drug Creation and Manufacturing Program |
2012ZX09304007 |
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| Corresponding Author |
Yuan-Lu Cui, Professor, Research Center of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No. 88 YuQuan Road, Nankai District, Tianjin 300193, China. cuiyl@tju.edu.cn |
| Key Words |
Salvia miltiorrhiza; Carthamus tinctorius; Apoptosis; Anti-inflammatory; Antioxidant; Acute liver injury |
| Core Tip |
Salvia miltiorrhiza and Carthamus tinctorius extract [Danhong injection (DHI)] effectively protected against hepatic injury. DHI intervention significantly reduced alanine transferase, aspartate transaminase, total bilirubin, malondialdehyde, glutathione-S-transferase, tumour necrosis factor-α, interleukin-6, and caspase-3 levels in an lipopolysaccharide (LPS)-induced mouse model of acute liver injury. Moreover, DHI antagonised LPS-induced Bcl-2 and Bax expression and inhibited IκBα and nuclear factor-κB p65 phosphorylation. These findings suggest that Salvia miltiorrhiza and Carthamus tinctorius extract (such as DHI) acts as a multi-function protectant against acute hepatic injury in mice through its anti-inflammatory, anti-oxidative and anti-apoptotic activities. |
| Publish Date |
2015-08-17 11:15 |
| Citation |
Gao LN, Yan K, Cui YL, Fan GW, Wang YF. Protective effect of Salvia miltiorrhiza and Carthamus tinctorius extract against lipopolysaccharide-induced liver injury. World J Gastroenterol 2015; 21(30): 9079-9092 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i30/9079.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i30.9079 |
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