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Articles Published Processes
8/20/2015 1:37:00 PM | Browse: 1029 | Download: 1825
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Received |
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2015-03-09 17:18 |
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Peer-Review Started |
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2015-03-10 08:02 |
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To Make the First Decision |
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2015-04-23 13:14 |
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Return for Revision |
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2015-04-30 16:04 |
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Revised |
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2015-05-21 17:19 |
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Second Decision |
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2015-06-08 08:24 |
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Accepted by Journal Editor-in-Chief |
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2015-06-08 20:18 |
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Accepted by Executive Editor-in-Chief |
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2015-06-26 15:08 |
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Articles in Press |
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2015-06-26 15:08 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-07-19 20:32 |
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Typeset the Manuscript |
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2015-08-06 11:41 |
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Publish the Manuscript Online |
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2015-08-20 13:37 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Mechanism of aqueous fructus aurantii immaturus extracts in neuroplexus of cathartic colons
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shi-Yi Wang, Yan-Ping Liu, Yi-Hong Fan, Lu Zhang, Li-Jun Cai and Bin Lv |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81473506 |
| Natural Science Foundation of Zhejiang Province |
LY13H030011 |
| State Administration of Traditional Chinese Medicine of Zhejiang Province |
2013ZB050 |
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| Corresponding Author |
Yi-Hong Fan, PhD, Associate Professor, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54, Youdian Road, Hangzhou 310006, Zhejiang Province, China. yhfansjr@163.com |
| Key Words |
Fructus aurantii immaturus; Aqueous extracts; Cathartic colon; 5-HTR4; Neurofilament; Myenteric plexus |
| Core Tip |
Bowel movements in cathartic colon can be strengthened with mosapride. However, recent studies show that aqueous fructus aurantii immaturus (FAI) extracts, a traditional Chinese medicine, can also strengthen bowel movements, and are widely used to treat gastrointestinal symptoms. The aim of this study was to identify the mechanism by which aqueous FAI extracts exert these effects. In a rat model of cathartic colons, treatment with mosapride and aqueous FAI extracts improved the intestinal transit rate, and increased the expression of 5-hydroxytryptamine receptor 4 and neurofilament-H. |
| Publish Date |
2015-08-20 13:37 |
| Citation |
Wang SY, Liu YP, Fan YH, Zhang L, Cai LJ, Lv B. Mechanism of aqueous fructus aurantii immaturus extracts in neuroplexus of cathartic colons. World J Gastroenterol 2015; 21(31): 9358-9366 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i31/9358.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i31.9358 |
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