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Articles Published Processes
8/20/2015 1:37:00 PM | Browse: 1143 | Download: 2165
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Received |
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2015-03-11 15:53 |
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Peer-Review Started |
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2015-03-12 08:29 |
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To Make the First Decision |
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2015-03-26 16:29 |
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Return for Revision |
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2015-04-01 14:24 |
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Revised |
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2015-06-17 00:55 |
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Second Decision |
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2015-07-03 20:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-07-08 17:14 |
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Articles in Press |
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2015-07-08 17:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-07-27 08:17 |
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Typeset the Manuscript |
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2015-08-05 12:04 |
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Publish the Manuscript Online |
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2015-08-20 13:37 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
MiR-30b suppresses tumor migration and invasion by targeting EIF5A2 in gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Shu-Bo Tian, Jian-Chun Yu, Wei-Ming Kang, Zhi-Qiang Ma, Xin Ye and Chao Yan |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Beijing Municipal Natural Science Foundation of China |
7132209 |
| Capital Health Research and Development of Special |
2014-3-4014 |
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| Corresponding Author |
Jian-Chun Yu, Professor, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. yujch_pumch@126.com |
| Key Words |
miR-30b; Gastric cancer; EIF5A2; Migration; Invasion |
| Core Tip |
In this study, we found that miR-30b expression was reduced in gastric cancer cell lines and in gastric cancer tissues. Moreover, we found that miR-30b inhibited gastric cancer cell proliferation, migration, invasion and promoted apoptosis by targeting EIF5A2. Restoration of miR-30b expression could enhance E-cadherin and β-catenin expression and suppress vimentin expression by targeting EIF5A2 and eventually inhibit the epithelial-to-mesenchymal transition (EMT) process in gastric cancer cells, whereas knockdown of miR-30b promoted cell invasion and EMT in cancer cells. |
| Publish Date |
2015-08-20 13:37 |
| Citation |
Tian SB, Yu JC, Liu YQ, Kang WM, Ma ZQ, Ye X, Yan C. miR-30b suppresses tumor migration and invasion by targeting EIF5A2 in gastric cancer. World J Gastroenterol 2015; 21(31): 9337-9347 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i31/9337.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i31.9337 |
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