Publication Name	World Journal of Gastroenterology
Manuscript ID	17517
Country	China

Received	2015-03-11 15:53
Peer-Review Started	2015-03-12 08:29
First Decision by Editorial Office Director
Return for Revision	2015-04-01 14:24
Revised	2015-06-17 00:55
Publication Fee Transferred
Second Decision by Editor	2015-07-03 20:52
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-07-08 17:14
Articles in Press	2015-07-08 17:14
Edit the Manuscript by Language Editor	2015-07-27 08:17
Typeset the Manuscript	2015-08-05 12:04
Publish the Manuscript Online	2015-08-20 13:37

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	MiR-30b suppresses tumor migration and invasion by targeting EIF5A2 in gastric cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Shu-Bo Tian, Jian-Chun Yu, Wei-Ming Kang, Zhi-Qiang Ma, Xin Ye and Chao Yan
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Municipal Natural Science Foundation of China 7132209 Capital Health Research and Development of Special 2014-3-4014
Corresponding Author	Jian-Chun Yu, Professor, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. yujch_pumch@126.com
Key Words	miR-30b; Gastric cancer; EIF5A2; Migration; Invasion
Core Tip	In this study, we found that miR-30b expression was reduced in gastric cancer cell lines and in gastric cancer tissues. Moreover, we found that miR-30b inhibited gastric cancer cell proliferation, migration, invasion and promoted apoptosis by targeting EIF5A2. Restoration of miR-30b expression could enhance E-cadherin and β-catenin expression and suppress vimentin expression by targeting EIF5A2 and eventually inhibit the epithelial-to-mesenchymal transition (EMT) process in gastric cancer cells, whereas knockdown of miR-30b promoted cell invasion and EMT in cancer cells.
Publish Date	2015-08-20 13:37
Citation	Tian SB, Yu JC, Liu YQ, Kang WM, Ma ZQ, Ye X, Yan C. miR-30b suppresses tumor migration and invasion by targeting EIF5A2 in gastric cancer. World J Gastroenterol 2015; 21(31): 9337-9347
URL	http://www.wjgnet.com/1007-9327/full/v21/i31/9337.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i31.9337

Full Article (PDF)	WJG-21-9337.pdf
Full Article (Word)	WJG-21-9337.doc
Manuscript File	17517-Review.docx
Answering Reviewers	17517-Answering reviewers.pdf
Audio Core Tip	17517-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17517-Conflict-of-interest statement.pdf
Copyright License Agreement	17517-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	17517-Institutional review board statement.pdf
Peer-review Report	17517-Peer-review(s).pdf
Scientific Misconduct Check	17517-Scientific misconduct check.pdf
Scientific Editor Work List	17517-Scientific editor work list.pdf