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8/20/2015 1:37:00 PM | Browse: 398 | Download: 757
Publication Name World Journal of Gastroenterology
Manuscript ID 17517
Country of Manuscript Source China
Received
2015-03-11 15:53
Peer-Review Started
2015-03-12 08:29
To Make the First Decision
2015-03-26 16:29
Return for Revision
2015-04-01 14:24
Revised
2015-06-17 00:55
Second Decision
2015-07-03 20:52
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-07-08 17:14
Articles in Press
2015-07-08 17:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-07-27 08:17
Typeset the Manuscript
2015-08-05 12:04
Publish the Manuscript Online
2015-08-20 13:37
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title MiR-30b suppresses tumor migration and invasion by targeting EIF5A2 in gastric cancer
Manuscript Source Unsolicited Manuscript
All Author List Shu-Bo Tian, Jian-Chun Yu, Wei-Ming Kang, Zhi-Qiang Ma, Xin Ye and Chao Yan
Funding Agency and Grant Number
Funding Agency Grant Number
Beijing Municipal Natural Science Foundation of China 7132209
Capital Health Research and Development of Special 2014-3-4014
Corresponding author Jian-Chun Yu, Professor, Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. yujch_pumch@126.com
Keywords miR-30b; Gastric cancer; EIF5A2; Migration; Invasion
Core Tip In this study, we found that miR-30b expression was reduced in gastric cancer cell lines and in gastric cancer tissues. Moreover, we found that miR-30b inhibited gastric cancer cell proliferation, migration, invasion and promoted apoptosis by targeting EIF5A2. Restoration of miR-30b expression could enhance E-cadherin and β-catenin expression and suppress vimentin expression by targeting EIF5A2 and eventually inhibit the epithelial-to-mesenchymal transition (EMT) process in gastric cancer cells, whereas knockdown of miR-30b promoted cell invasion and EMT in cancer cells.
Publish Date 2015-08-20 13:37
Citation Tian SB, Yu JC, Liu YQ, Kang WM, Ma ZQ, Ye X, Yan C. miR-30b suppresses tumor migration and invasion by targeting EIF5A2 in gastric cancer. World J Gastroenterol 2015; 21(31): 9337-9347
Url http://www.wjgnet.com/1007-9327/full/v21/i31/9337.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i31.9337
Full Article (PDF) WJG-21-9337.pdf
Full Article (Word) WJG-21-9337.doc
Manuscript File 17517-Review.docx
Answering Reviewers 17517-Answering reviewers.pdf
Audio Core Tip 17517-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 17517-Conflict-of-interest statement.pdf
Copyright License Agreement 17517-Copyright assignment.pdf
Data Sharing Statement 17517-Data sharing statement.pdf
Institutional Review Board Approval Form or Document 17517-Institutional review board statement.pdf
Peer-review Report 17517-Peer-review(s).pdf
Scientific Misconduct Check 17517-Scientific misconduct check.pdf
Scientific Editor Work List 17517-Scientific editor work list.pdf