Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	17596
Country	United States

Received	2015-03-16 09:30
Peer-Review Started	2015-03-16 19:49
To Make the First Decision	2015-04-10 17:41
Return for Revision	2015-04-17 09:41
Revised	2015-04-24 11:36
Second Decision	2015-05-04 19:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-05-11 14:20
Articles in Press	2015-05-11 14:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-16 15:06
Publish the Manuscript Online	2015-07-08 09:21

ISSN	1948-5190 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Gastrointestinal endoscopy biopsy derived proteomic patterns predict indeterminate colitis into ulcerative colitis and Crohn’s colitis
Manuscript Source	Invited Manuscript
All Author List	Billy Ray Ballard and Amosy Ephreim M’Koma
Funding Agency and Grant Number	Funding Agency Grant Number NIH/NIDDK R21DK095186-01A1 3U54 CA091408–09S1 NIH/NIDDK R21DK095186-01A1 U54RR026140/U54MD007593 NIH/NIDDK R21DK095186-01A1 UL1 RR024975 Research Foundation, American Society of Colon and Rectal Surgeons, Limited Project LPG-086
Corresponding Author	Amosy Ephreim M’Koma, MD, MS, PhD, Department of Biochemistry and Cancer Biology, Meharry Medical College School of Medicine, 1005 Dr. D. B. Todd Jr. Boulevard, Nashville, TN 37208-3599, United States. amkoma@mmc.edu
Key Words	Indeterminate; Ulcerative; Crohn’s colitis; The colitides; Proteomics; Diagnostic accuracy
Core Tip	This Editorial is introductory, dedicated to a novel and innovative study with clinical relevance regarding precision of indeterminate colitis (IC) into accurate diagnosis of either ulcerative colitis (UC) or Crohn’s colitis (CC). To date, it is very difficult to predict the clinical course of IC, whether it will evolve into UC or CC. About 90% of IC is diagnosed at the time of colectomy for fulminant colitis and subsequent management critically depends on the correct eventual diagnosis. The outcome after colectomy and pouch anastomosis may be painstaking if IC turns into CC. The undergoing studies of proteomic analysis on colon biopsy specimens, if successful will permit delineate IC into UC or CC precision which could be of great help in decision making regarding treatment indication. Although the present data is convincing and support differentiated between UC and CC, this data requires validation and confirmation on a large scale by clinical studies. Hopefully, this editorial will stimulate research into this field to trying to overcome the diagnostic accuracy challenges in inflammatory bowel diseases.
Publish Date	2015-07-08 09:21
Citation	Ballard BR, M’Koma AE. Gastrointestinal endoscopy biopsy derived proteomic patterns predict indeterminate colitis into ulcerative colitis and Crohn’s colitis. World J Gastrointest Endosc 2015; 7(7): 670-674
URL	http://www.wjgnet.com/1948-5190/full/v7/i7/670.htm
DOI	http://dx.doi.org/10.4253/wjge.v7.i7.670

Full Article (PDF)	WJGE-7-670.pdf
Full Article (Word)	WJGE-7-670.doc
Manuscript File	17596-Review.doc
Answering Reviewers	17596-Answering reviewers.pdf
Audio Core Tip	17596-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	17596-Conflict-of-interest statement.pdf
Copyright License Agreement	17596-Copyright assignment.pdf
Peer-review Report	17596-Peer-review(s).pdf
Scientific Misconduct Check	17596-Scientific misconduct check.pdf
Scientific Editor Work List	17596-Scientific editor work list.pdf