Publication Name	World Journal of Gastroenterology
Manuscript ID	17608
Country	China

Received	2015-03-15 10:07
Peer-Review Started	2015-03-15 12:09
To Make the First Decision	2015-04-13 14:07
Return for Revision	2015-04-27 08:11
Revised	2015-06-03 00:00
Second Decision	2015-06-23 18:27
Accepted by Journal Editor-in-Chief	2015-06-24 01:56
Accepted by Company Editor-in-Chief	2015-06-26 15:15
Articles in Press	2015-06-26 15:17
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-07-28 12:34
Typeset the Manuscript	2015-08-28 11:41
Publish the Manuscript Online	2015-09-14 16:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Development of a rat model of D-galactosamine/lipopolysaccharide induced hepatorenal syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Jing-Bo Wang, Hai-Tao Wang, Lu-Ping Li, Ying-Chun Yan, Wei Wang, Jing-Yang Liu, Yi-Tong Zhao, Wei-Shu Gao and Ming-Xiang Zhang
Funding Agency and Grant Number
Corresponding Author	Ming-Xiang Zhang, Professor, Cirrhosis Treatment Center, the Sixth People′s Hospital of Shenyang, 85 Hepingnan Street, Heping District, Shenyang 110006, Liaoning Province, China. zhangmingxiang2014@126.com
Key Words	Hepatorenal syndrome; Animal model; Rat; D-galactosamine; Lipopolysaccharide
Core Tip	In this article, D-galactosamine was injected into SD rats via the caudal vein to establish a model of hepatorenal syndrome (HRS). Twelve hours after injection, serum level of tumor necrosis factor-alpha was significantly elevated while the glomerular filtration rate was significantly lowered. Hepatorenal function became obviously abnormal. Pathological findings showed massive necrosis of liver cells but normal kidney structure. Our animal model provided a good simulation of partial pathophysiological process of human HRS.
Publish Date	2015-09-14 16:54
Citation	Wang JB, Wang HT, Li LP, Yan YC, Wang W, Liu JY, Zhao YT, Gao WS, Zhang MX. Development of a rat model of D-galactosamine/lipopolysaccharide induced hepatorenal syndrome. World J Gastroenterol 2015; 21(34): 9927-9935
URL	http://www.wjgnet.com/1007-9327/full/v21/i34/9927.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i34.9927

Full Article (PDF)	WJG-21-9927.pdf
Full Article (Word)	WJG-21-9927.doc
Manuscript File	17608-Review.doc
Answering Reviewers	17608-Answering reviewers.pdf
Audio Core Tip	17608-Audio core tip.wav
Conflict-of-Interest Disclosure Form	17608-Conflict-of-interest statement.pdf
Copyright License Agreement	17608-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	17608-Institutional animal care and use committee statement.pdf
Peer-review Report	17608-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17608-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17608-Scientific misconduct check.pdf
Scientific Editor Work List	17608-Scientific editor work list.pdf