Publication Name	World Journal of Gastroenterology
Manuscript ID	1761
Country	Canada

Received	2013-01-04 09:38
Peer-Review Started	2013-01-04 11:50
To Make the First Decision	2013-03-11 15:14
Return for Revision	2013-03-19 17:18
Revised	2013-03-26 12:51
Second Decision	2013-04-03 15:27
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-04-04 04:14
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-05-17 16:21
Publish the Manuscript Online	2013-06-04 12:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Varicella zoster meningitis complicating combined anti-tumor necrosis factor and corticosteroid therapy in Crohn's disease
Manuscript Source	Invited Manuscript
All Author List	Christopher Ma, Brennan Walters and Richard N Fedorak
Funding Agency and Grant Number	Funding Agency Grant Number Abbott Canada to Fedorak RN
Corresponding Author	Richard N Fedorak, MD, FRCPC, Associate Vice President, Professor of Medicine, Division of Gastroenterology, University of Alberta, 2-14A Zeidler Building, Edmonton, AL T6G 2X8, Canada. richard.fedorak@ualberta.ca
Key Words	Varicella zoster virus; Meningitis; Crohn's disease; Adalimumab; Infliximab; corticosteroids; Anti-tumor necrosis factor
Core Tip	Opportunistic viral infections can complicate anti-tumor necrosis factor (TNF) therapy for inflammatory bowel disease (IBD). Central nervous system varicella zoster virus (VZV) infections associated with the use of anti-TNF therapy have not been previously described in Crohn's disease patients. We present the first reported case of VZV meningitis in a 40-year-old male with Crohn's disease who developed reactivation dermatomal herpes zoster and VZV meningitis after treatment with adalimumab and prednisone. Despite aggressive antiviral therapy, he had significant morbidity, highlighting the risk of opportunistic viral infections in this population and the importance of vaccination before anti-TNF therapy.
Publish Date	2013-06-04 12:34
Citation	Ma C, Walters B, Fedorak RN. Varicella zoster meningitis complicating combined anti-tumor necrosis factor and corticosteroid therapy in Crohn’s disease. World J Gastroenterol 2013; 19(21): 3347-3351
URL	http://www.wjgnet.com/1007-9327/full/v19/i21/3347.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i21.3347

Full Article (PDF)	WJG-19-3347.pdf
Manuscript File	1761-Review.doc
Answering Reviewers	1761-Answering reviewers.docx
Copyright License Agreement	1761-Copyright assignment.pdf
Peer-review Report	1761-Peer review(s).pdf
Scientific Editor Work List	1761-Scientific editor work list.doc