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Articles Published Processes
9/7/2015 4:31:00 PM | Browse: 1173 | Download: 2635
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Received |
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2015-03-15 12:02 |
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Peer-Review Started |
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2015-03-15 12:23 |
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To Make the First Decision |
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2015-04-13 14:09 |
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Return for Revision |
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2015-04-15 18:02 |
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Revised |
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2015-06-06 10:05 |
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Second Decision |
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2015-06-23 18:27 |
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Accepted by Journal Editor-in-Chief |
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2015-06-24 01:55 |
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Accepted by Executive Editor-in-Chief |
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2015-06-26 15:16 |
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Articles in Press |
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2015-06-26 15:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-07-19 20:32 |
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Typeset the Manuscript |
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2015-08-19 18:36 |
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Publish the Manuscript Online |
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2015-09-07 16:31 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular carcinoma cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Bing Han, Shi-Hai Liu, Wei-Dong Guo, Bin Zhang, Jian-Ping Wang, Yu-Kun Cao and Jun Liu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Shandong Provincial Natural Science Foundation, China |
ZR2012HQ039 |
| Shandong Provincial Natural Science Foundation, China |
ZR2014HP065 |
| National Natural Science Foundation of China |
81373172 |
| National Natural Science Foundation of China |
81402579 |
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| Corresponding Author |
Jun Liu, MD, PhD, Professor, Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University, No. 324 Jingwu Road, Jinan 250021, Shandong Province, China. dr_junliu@163.com |
| Key Words |
Notch signaling pathway; Interleukin-24; γ-secretase inhibitor; Invasion; Migration; Hepatocellular carcinoma |
| Core Tip |
The down-regulation of Notch1 by γ-secretase inhibitor (GSI-I) or siRNA combined with interleukin (IL)-24, could sensitize apoptosis, increase expression of E-cadherin and decrease the invasion and migration capabilities of HepG2 cells. These results indicate for the first time that GSI-I/IL-24 combination might represent a novel and potentially effective tool for hepatocellular carcinoma treatment. |
| Publish Date |
2015-09-07 16:31 |
| Citation |
Han B, Liu SH, Guo WD, Zhang B, Wang JP, Cao YK, Liu J. Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular carcinoma cells. World J Gastroenterol 2015; 21(33): 9727-9735 |
| URL |
http://www.wjgnet.com/1007-9327/full/v21/i33/9727.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v21.i33.9727 |
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