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Articles Published Processes
1/21/2016 4:10:00 PM | Browse: 1225 | Download: 2703
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Received |
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2015-03-15 11:51 |
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Peer-Review Started |
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2015-03-15 12:43 |
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To Make the First Decision |
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2015-04-13 14:11 |
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Return for Revision |
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2015-04-15 18:45 |
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Revised |
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2015-06-10 20:08 |
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Second Decision |
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2015-07-27 20:13 |
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Accepted by Journal Editor-in-Chief |
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2015-07-28 13:44 |
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Accepted by Executive Editor-in-Chief |
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2015-08-25 18:14 |
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Articles in Press |
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2015-08-25 18:14 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2015-10-11 21:32 |
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Typeset the Manuscript |
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2015-11-24 10:32 |
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Publish the Manuscript Online |
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2016-01-21 16:10 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Chymase inhibitor TY-51469 in therapy of inflammatory bowel disease
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei-Xin Liu, Ying Wang, Li-Xuan Sang, Shen Zhang, Ting Wang, Feng Zhou and Shou-Zhi Gu |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Project of Liaoning Province |
2013225303 |
| Science and Technology Project of Shenyang City |
F13-316-1-40 |
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| Corresponding Author |
Wei-Xin Liu, Professor, Department of Gastroenterology, First Affiliated Hospital, China Medical University, No. 155 North Nanjing Street, Heping District, Shenyang 110001, Liaoning Province, China. weixinliu@yahoo.com
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| Key Words |
Chymase inhibitor; Tregs; Inflammatory bowel disease; Cytokines; Rats |
| Core Tip |
Until now, little is known of the role of chymase inhibitor in the immune system and no investigation has been performed in inflammatory bowel disease (IBD). In the present study, we built a Sprague-Dawley rat model of colitis induced with dextran sulfate sodium (DSS) and treated the model rats with chymase inhibitor TY-51469. The changes of Tregs were further detected to investigate the effect of chymase inhibitor TY-51469 on IBD and to explore the underlying mechanism. The results indicated that chymase inhibitor TY-51469 might ameliorate the progression of DSS-induced colitis possibly by increasing the expression of Tregs and cytokines.
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| Publish Date |
2016-01-21 16:10 |
| Citation |
Liu WX, Wang Y, Sang LX, Zhang S, Wang T, Zhou F, Gu SZ. Chymase inhibitor TY-51469 in therapy of inflammatory bowel disease. World J Gastroenterol 2016; 22(5): 1826-1833 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i5/1826.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i5.1826 |
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