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1/21/2016 4:10:00 PM | Browse: 582 | Download: 1083
Publication Name World Journal of Gastroenterology
Manuscript ID 17618
Country/Territory China
Received
2015-03-15 11:51
Peer-Review Started
2015-03-15 12:43
To Make the First Decision
2015-04-13 14:11
Return for Revision
2015-04-15 18:45
Revised
2015-06-10 20:08
Second Decision
2015-07-27 20:13
Accepted by Journal Editor-in-Chief
2015-07-28 13:44
Accepted by Company Editor-in-Chief
2015-08-25 18:14
Articles in Press
2015-08-25 18:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
2015-10-11 21:32
Typeset the Manuscript
2015-11-24 10:32
Publish the Manuscript Online
2016-01-21 16:10
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Chymase inhibitor TY-51469 in therapy of inflammatory bowel disease
Manuscript Source Unsolicited Manuscript
All Author List Wei-Xin Liu, Ying Wang, Li-Xuan Sang, Shen Zhang, Ting Wang, Feng Zhou and Shou-Zhi Gu
Funding Agency and Grant Number
Funding Agency Grant Number
Science and Technology Project of Liaoning Province 2013225303
Science and Technology Project of Shenyang City F13-316-1-40
Corresponding author Wei-Xin Liu, Professor, Department of Gastroenterology, First Affiliated Hospital, China Medical University, No. 155 North Nanjing Street, Heping District, Shenyang 110001, Liaoning Province, China. weixinliu@yahoo.com
Keywords Chymase inhibitor; Tregs; Inflammatory bowel disease; Cytokines; Rats
Core Tip Until now, little is known of the role of chymase inhibitor in the immune system and no investigation has been performed in inflammatory bowel disease (IBD). In the present study, we built a Sprague-Dawley rat model of colitis induced with dextran sulfate sodium (DSS) and treated the model rats with chymase inhibitor TY-51469. The changes of Tregs were further detected to investigate the effect of chymase inhibitor TY-51469 on IBD and to explore the underlying mechanism. The results indicated that chymase inhibitor TY-51469 might ameliorate the progression of DSS-induced colitis possibly by increasing the expression of Tregs and cytokines.
Publish Date 2016-01-21 16:10
Citation Liu WX, Wang Y, Sang LX, Zhang S, Wang T, Zhou F, Gu SZ. Chymase inhibitor TY-51469 in therapy of inflammatory bowel disease. World J Gastroenterol 2016; 22(5): 1826-1833
Url http://www.wjgnet.com/1007-9327/full/v22/i5/1826.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i5.1826
Full Article (PDF) WJG-22-1826.pdf
Full Article (Word) WJG-22-1826.doc
Manuscript File 17618-Review.doc
Answering Reviewers 17618-Answering reviewers.pdf
Audio Core Tip 17618-Audio core tip.mp3
Biostatistics Review Certificate 17618-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 17618-Conflict-of-interest statement.pdf
Copyright License Agreement 17618-Copyright assignment.pdf
Data Sharing Statement 17618-Data sharing statement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 17618-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 17618-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 17618-Language certificate.pdf
Peer-review Report 17618-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 17618-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 17618-Scientific misconduct check.pdf
Scientific Editor Work List 17618-Scientific editor work list.pdf