Publication Name	World Journal of Cardiology
Manuscript ID	17640
Country	United Kingdom

Received	2015-03-16 16:09
Peer-Review Started	2015-03-17 16:47
To Make the First Decision	2015-04-10 17:26
Return for Revision	2015-04-15 12:16
Revised	2015-04-29 07:11
Second Decision	2015-05-25 12:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-06-02 17:38
Articles in Press	2015-06-02 17:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-14 19:22
Publish the Manuscript Online	2015-08-27 11:20

ISSN	1949-8462 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Cardiac & Cardiovascular Systems
Manuscript Type	Minireviews
Article Title	Early repolarization syndrome: A cause of sudden cardiac death
Manuscript Source	Invited Manuscript
All Author List	Abdi Ali, Nida Butt and Azeem S Sheikh
Funding Agency and Grant Number
Corresponding Author	Azeem S Sheikh, BSc, MBBS, FCPS, MRCP, Specialist Registrar in Cardiology, Wrexham Maelor Hospital, Croesnewydd Road, Wrexham, Wales LL13 7TZ, United Kingdom. drazeemsheikh@hotmail.com
Key Words	Early repolarization syndrome; Early repolarization; Sudden cardiac death; J-wave
Core Tip	Early repolarization syndrome (ERS), demon-strated as J-point elevation on an electrocar-diograph, was formerly thought to be a benign entity, but the recent studies have demonstrated that it can be linked to a higher risk of ventricular arrhythmias and sudden cardiac death. The prevalence of ERS varies between 3% and 24%, depending on age, sex and J-point elevation (0.05 mV vs 0.1 mV) being the main determinants. ERS patients are sporadic and they are at a higher risk of having recurrent cardiac events. Implantable cardioverter-defibrillator implantation and isoproterenol are the suggested therapies in this set of patients. On the other hand, asymptomatic patients with ERS are common and have a better prognosis. The risk stratification in asymptomatic patients with ERS still remains a grey area. This review provides an outline of the up-to-date evidence associated with ERS and the risk of life - threatening arrhythmias. Further prospective studies are required to elucidate the mechanisms of ventricular arrhythmogenesis in patients with ERS.
Publish Date	2015-08-27 11:20
Citation	Ali A, Butt N, Sheikh AS. Early repolarization syndrome: A cause of sudden cardiac death. World J Cardiol 2015; 7(8): 466-475
URL	http://www.wjgnet.com/1949-8462/full/v7/i8/466.htm
DOI	http://dx.doi.org/10.4330/wjc.v7.i8.466

Full Article (PDF)	WJC-7-466.pdf
Full Article (Word)	WJC-7-466.doc
Manuscript File	17640-Review.doc
Answering Reviewers	17640-Answering reviewers.pdf
Audio Core Tip	17640-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17640-Conflict-of-interest statement.pdf
Copyright License Agreement	17640-Copyright assignment.pdf
Peer-review Report	17640-Peer-review(s).pdf
Scientific Misconduct Check	17640-Scientific misconduct check.pdf
Scientific Editor Work List	17640-Scientific editor work list.pdf