Publication Name	World Journal of Gastroenterology
Manuscript ID	17659
Country	Japan

Received	2015-03-17 18:40
Peer-Review Started	2015-03-18 08:55
To Make the First Decision	2015-04-23 14:44
Return for Revision	2015-04-28 19:57
Revised	2015-05-21 12:54
Second Decision	2015-08-03 10:12
Accepted by Journal Editor-in-Chief	2015-08-05 09:44
Accepted by Executive Editor-in-Chief	2015-08-31 15:58
Articles in Press	2015-08-31 15:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-08 11:29
Publish the Manuscript Online	2015-09-28 18:06

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Topic Highlights
Article Title	Biomarkers for the early diagnosis of hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Nobuhiro Tsuchiya, Yu Sawada, Itaru Endo, Keigo Saito, Yasushi Uemura and Tetsuya Nakatsura
Funding Agency and Grant Number
Corresponding Author	Tetsuya Nakatsura, MD, PhD, Chief, Division of Cancer Immunotherapy, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa 277-8577, Japan. tnakatsu@east.ncc.go.jp
Key Words	α-fetoprotein; α-fetoprotein-L3; Biomarker; Des-γ-carboxyprothrombin; Glypican-3; Golgi protein-73; Hepatocellular carcinoma; MicroRNAs; Osteopontin; Squamous cell carcinoma antigen
Core Tip	Hepatocellular carcinoma (HCC) is the fifth most common cancer and the second leading cause of cancer-related death worldwide. The poor prognosis of HCC is due to the fact that diagnosis is often made at a late stage in disease development. Thus, the identification of biomarkers for diagnosis at an early stage may result in significant benefits. An up-to-date review of biomarkers that are currently used for the early diagnosis of HCC is provided in this article.
Publish Date	2015-09-28 18:06
Citation	Tsuchiya N, Sawada Y, Endo I, Saito K, Uemura Y, Nakatsura T. Biomarkers for the early diagnosis of hepatocellular carcinoma. World J Gastroenterol 2015; 21(37): 10573-10583
URL	http://www.wjgnet.com/1007-9327/full/v21/i37/10573.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i37.10573

Full Article (PDF)	WJG-21-10573.pdf
Full Article (Word)	WJG-21-10573.doc
Manuscript File	17659-Review.docx
Answering Reviewers	17659-Answering reviewers.pdf
Audio Core Tip	17659-Audio core tip.wma
Conflict-of-Interest Disclosure Form	17659-Conflict-of-interest statement.pdf
Copyright License Agreement	17659-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	17659-Language certificate.pdf
Peer-review Report	17659-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	17659-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	17659-Scientific misconduct check.pdf
Scientific Editor Work List	17659-Scientific editor work list.pdf