Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	17667
Country	India

Received	2015-03-18 09:31
Peer-Review Started	2015-03-21 20:23
To Make the First Decision	2015-04-10 17:29
Return for Revision	2015-04-15 13:26
Revised	2015-05-14 23:51
Second Decision	2015-05-25 12:05
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-06-02 17:41
Articles in Press	2015-06-02 17:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-07-02 10:58
Publish the Manuscript Online	2015-07-14 12:20

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Case Control Study
Article Title	Association of endothelial nitric oxide synthase gene T-786C promoter polymorphism with gastric cancer
Manuscript Source	Invited Manuscript
All Author List	Devulapalli Krishnaveni, Bhayal Amar Chand, Porika Shravan Kumar, Malladi Uma Devi, Macherla Ramanna, Akka Jyothy, Nallari Pratibha, N Balakrishna and Ananthapur Venkateshwari
Funding Agency and Grant Number
Corresponding Author	Dr. Ananthapur Venkateshwari, Assistant Professor, Department of Cell Biology, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, India. venkateshwari@yahoo.com
Key Words	Genetics; Helicobacter pylori; Nutrition; Oncology; Endoscopy; Gastro duodenal; Nitric oxide; Single nucleotide polymorphism rs2070744; Agarose gel electrophoresis; Allele specific polymerase chain reaction
Core Tip	The present study reveals first molecular epidemiological evidence from south Indian cohort for the association of endothelial nitric oxide synthase -786T > C promoter polymorphism with a risk to develop gastric cancer (GC). The CC genotype and C allele of the -786T > C polymorphism were significantly associated with an elevated risk to GC, probably due to the lowered nitric oxide levels in case of C/C genotype which result in tumour proliferation, angiogenesis and metastasis.
Publish Date	2015-07-14 12:20
Citation	Krishnaveni D, Amar Chand B, Shravan Kumar P, Uma Devi M, Ramanna M, Jyothy A, Pratibha N, Balakrishna N, Venkateshwari A. Association of endothelial nitric oxide synthase gene T-786C promoter polymorphism with gastric cancer. World J Gastrointest Oncol 2015; 7(7): 87-94
URL	http://www.wjgnet.com/1948-5204/full/v7/i7/87.htm
DOI	http://dx.doi.org/10.4251/wjgo.v7.i7.87

Full Article (PDF)	WJGO-7-87.pdf
Full Article (Word)	WJGO-7-87.doc
Manuscript File	17667-Review.docx
Answering Reviewers	17667-Answering reviewers.pdf
Audio Core Tip	17667-Audio core tip.MP3
Biostatistics Review Certificate	17667-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	17667-Conflict-of-interest statement.pdf
Copyright License Agreement	17667-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150317204106.docx
Institutional Review Board Approval Form or Document	17667-Institutional review board statement.PDF
Peer-review Report	17667-Peer-review(s).pdf
Scientific Misconduct Check	17667-Scientific misconduct check.pdf
Scientific Editor Work List	17667-Scientific editor work list.pdf