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Articles Published Processes
10/19/2015 4:02:00 PM | Browse: 1339 | Download: 2187
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Received |
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2015-03-18 15:57 |
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Peer-Review Started |
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2015-03-18 21:29 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2015-04-28 19:43 |
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Revised |
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2015-05-07 13:34 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2015-08-10 08:23 |
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Second Decision by Editor-in-Chief |
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2015-08-10 15:06 |
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Final Decision by Editorial Office Director |
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2015-09-07 08:21 |
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Articles in Press |
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2015-09-07 08:21 |
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Edit the Manuscript by Language Editor |
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2015-09-09 16:26 |
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Typeset the Manuscript |
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2015-09-24 10:28 |
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Publish the Manuscript Online |
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2015-10-19 16:02 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Contribution of the toxic advanced glycation end-products-receptor axis in nonalcoholic steatohepatitis-related hepatocellular carcinoma
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jun-ichi Takino, Kentaro Nagamine, Takamitsu Hori, Akiko Sakasai-Sakai and Masayoshi Takeuchi |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Japan Society for the Promotion of Science (JSPS) KAKENHI |
22300264 |
| Japan Society for the Promotion of Science (JSPS) KAKENHI |
25282029 (to Takeuchi M) |
| Ministry of Education, Culture, Sports, Science |
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| Technology (MEXT), Regional Innovation Strategy Support Program |
to Takeuchi M |
| Kanazawa Medical University |
SR2012-04 |
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| Corresponding Author |
Masayoshi Takeuchi, PhD, Department of Advanced Medicine, Medical Research Institute, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku, Ishikawa 920-0293, Japan. takeuchi@kanazawa-med.ac.jp
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| Key Words |
Hepatocellular carcinoma; Nonalcoholic steatohepatitis; Advanced glycation end-products; Toxic advanced glycation end-products; Receptor for advanced glycation end-products; Hepatic stellate cells |
| Core Tip |
Expression of the receptor for advanced glycation end-products (RAGE), which is a multi-ligand cell surface receptor, is correlated with the poor therapeutic outcomes and malignancy of hepatocellular carcinoma (HCC). The synthesis of toxic advanced glycation end-products (TAGE), ligands of RAGE, is increased in nonalcoholic steatohepatitis (NASH) as well as in NASH-related HCC. Interactions between TAGE and RAGE induce oxidative stress, which may, in turn, lead to adverse effects in tumor cells and hepatic stellate cells during NASH or NASH-related HCC progression. Therefore, these findings prompted us to suggest that the TAGE-RAGE axis may be a treatment target in NASH-related HCC.
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| Publish Date |
2015-10-19 16:02 |
| Citation |
Takino J, Nagamine K, Hori T, Sakasai-Sakai A, Takeuchi M. Contribution of the toxic advanced glycation end-products-receptor axis in nonalcoholic steatohepatitis-related hepatocellular carcinoma. World J Hepatol 2015; 7(23): 2459-2469 |
| URL |
http://www.wjgnet.com/1948-5182/full/v7/i23/2459.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v7.i23.2459 |
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