Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	17707
Country	Italy

Received	2015-03-20 08:31
Peer-Review Started	2015-03-21 12:13
To Make the First Decision	2015-04-10 17:31
Return for Revision	2015-04-15 13:35
Revised	2015-06-10 02:00
Second Decision	2015-07-02 09:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-07-14 09:42
Articles in Press	2015-07-14 09:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-09 17:54
Publish the Manuscript Online	2015-09-29 10:43

ISSN	1948-9366 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Surgery
Manuscript Type	Editorial
Article Title	Detection methods and clinical significance of free peritoneal tumor cells found during colorectal cancer surgery
Manuscript Source	Invited Manuscript
All Author List	Simone Sibio, Cristina Fiorani, Carmine Stolfi, Andrea Divizia, Roberto Pezzuto, Fabrizio Montagnese, Giulia Bagaglini, Paolo Sammartino and Giuseppe Sigismondo Sica
Funding Agency and Grant Number
Corresponding Author	Giuseppe Sigismondo Sica, MD, PhD, Department of Surgical Science, Tor Vergata University of Rome, viale Oxford 81, 00133 Rome, Italy. sigisica@gmail.com
Key Words	Colorectal cancer; Cytology; Free cancer cells; Peritoneal recurrence; Proactive treatment
Core Tip	This invited editorial looks for the role of intra-peritoneal free cancer cells (IFCC) in the surgical practice for colorectal cancer. Prognostic significance of IFCC in colorectal cancer patients is still not clear. Several studies have been published but detection systems are still highly heterogeneous and results remain misleading. Peritoneal cytology could be useful in early-stage cancers to identify subsets of patients with potential worse prognosis, who may be good candidates for adjuvant treatment or even prophylactic intraperitoneal chemotherapy. Current available data need stronger validation to include IFCC in the routine staging protocols of colorectal cancer patients. However, it is the authors’ belief that cancer cells found free in the peritoneum of patients with colon cancer, must have a biological and a clinical role. The means of detection based on real time polymerase chain reaction, will surely add power to conventional cytology and with the improvement in sensibility of the methods the clinical role of IFCC could eventually become clear. New therapy protocols might be applied.
Publish Date	2015-09-29 10:43
Citation	Sibio S, Fiorani C, Stolfi C, Divizia A, Pezzuto R, Montagnese F, Bagaglini G, Sammartino P, Sica GS. Detection methods and clinical significance of free peritoneal tumor cells found during colorectal cancer surgery. World J Gastrointest Surg 2015; 7(9): 178-184
URL	http://www.wjgnet.com/1948-9366/full/v7/i9/178.htm
DOI	http://dx.doi.org/10.4240/wjgs.v7.i9.178

Full Article (PDF)	WJGS-7-178.pdf
Full Article (Word)	WJGS-7-178.doc
Manuscript File	17707-Review.docx
Answering Reviewers	17707-Answering reviewers.pdf
Audio Core Tip	17707-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	17707-Conflict-of-interest statement.pdf
Copyright License Agreement	17707-Copyright assignment.pdf
Peer-review Report	17707-Peer-review(s).pdf
Scientific Misconduct Check	17707-Scientific misconduct check.pdf
Scientific Editor Work List	17707-Scientific editor work list.pdf