Publication Name	World Journal of Gastroenterology
Manuscript ID	17710
Country	Spain

Received	2015-03-20 08:30
Peer-Review Started	2015-03-20 10:05
To Make the First Decision	2015-04-23 14:43
Return for Revision	2015-04-28 19:12
Revised	2015-05-07 21:24
Second Decision	2015-06-26 09:47
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-07-03 16:59
Articles in Press	2015-07-03 17:00
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-08-26 16:16
Publish the Manuscript Online	2015-09-28 11:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient
Manuscript Source	Unsolicited Manuscript
All Author List	Maria Salvado, Victor Vargas, Marta Vidal, Macarena Simon-Talero, Jessica Camacho and Josep Gamez
Funding Agency and Grant Number	Funding Agency Grant Number Spanish Fondo de Investigaciones Sanitarias PI13-01272 (to Gamez J) Interlaken Research Awards Program
Corresponding Author	Josep Gamez, MD, PhD, ALS Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Research Institute, Autonomous University of Barcelona, Passeig Vall d'Hebron, 119, Barcelona, Spain. josepgamez.bcn@gmail.com
Key Words	Drug-induced liver injury; Masitinib; Amyotrophic lateral sclerosis; Tirosine kinase inhibitors; Autoimmunity; Autoimmune-like hepatitis; Idiosyncratic drug hepatotoxicity
Core Tip	Physicians must be aware of the possibility of drug-induced liver injury in clinical trials, despite the drug having been shown to be of limited hepatotoxicity when tested in phase?Ⅰ-Ⅱ trials. We present an example of a patient resembling an autoimmune hepatitis. Despite discontinuing masitinib, the transaminases did not return to their baseline values for five months.
Publish Date	2015-09-28 11:42
Citation	Salvado M, Vargas V, Vidal M, Simon-Talero M, Camacho J, Gamez J. Autoimmune-like hepatitis during masitinib therapy in an amyotrophic lateral sclerosis patient. World J Gastroenterol 2015; 21(36): 10475-10479
URL	http://www.wjgnet.com/1007-9327/full/v21/i36/10475.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i36.10475

Full Article (PDF)	WJG-21-10475.pdf
Full Article (Word)	WJG-21-10475.doc
Manuscript File	17710-Review.docx
Answering Reviewers	17710-Answering reviewers.pdf
Audio Core Tip	17710-Audio core tip.mp3
Clinical Trial Registration Statement	17710-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	17710-Conflict-of-interest statement.pdf
Copyright License Agreement	17710-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	17710-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	17710-Language certificate.pdf
Peer-review Report	17710-Peer-review(s).pdf
Scientific Misconduct Check	17710-Scientific misconduct check.pdf
Scientific Editor Work List	17710-Scientific editor work list.pdf