Publication Name	World Journal of Gastroenterology
Manuscript ID	1773
Country	Japan

Received	2013-01-05 12:08
Peer-Review Started	2013-01-05 14:35
To Make the First Decision	2013-03-04 13:57
Return for Revision	2013-04-02 15:00
Revised	2013-04-20 08:30
Second Decision	2013-05-16 20:15
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-05-17 09:56
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-28 10:39
Publish the Manuscript Online	2013-07-06 17:46

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Differential mucin phenotypes and their significance in a variation of colorectal carcinoma
Manuscript Source	Invited Manuscript
All Author List	Yasuo Imai, Hidetsugu Yamagishi, Kazunori Fukuda, Yuko Ono, Tohru Inoue and Yoshihiko Ueda
Funding Agency and Grant Number	Funding Agency Grant Number Haraguchi Memorial Trust Fund
Corresponding Author	Yasuo Imai, MD, Department of Pathology, Dokkyo Medical University Koshigaya Hospital, Minami-Koshigaya, Koshigaya, Saitama 343-8555, Japan. ya-imai@dokkyomed.ac.jp
Key Words	Mucin 2; Mucin 5AC; Microsatellite instability; Mismatch repair; Colorectal carcinoma; Poorly differentiated adenocarcinoma; Pathogenesis; Adenoma-carcinoma sequence; Prognosis
Core Tip	Altered mucin expression may be correlated with biological behavior and possibly with the prognosis of colorectal carcinoma (CRC). However, many contradictory results make it difficult to interpret its clinical significance, possibly because of CRC variations. Therefore, we examined mucin (MUC)2 and MUC5AC expressions in different pathological CRC subtypes by immunohistochemistry to determine their true clinical significance. Our results suggest that the expression profiles and the clinical significance of these mucin core proteins are different according to histological subtypes. This may reflect different pathogeneses for these tumors.
Publish Date	2013-07-06 17:46
Citation	Imai Y, Yamagishi H, Fukuda K, Ono Y, Inoue T, Ueda Y. Differential mucin phenotypes and their significance in a variation of colorectal carcinoma. World J Gastroenterol 2013; 19(25): 3957-3968
URL	http://www.wjgnet.com/1007-9327/full/v19/i25/3957.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i25.3957

Full Article (PDF)	WJG-19-3957.pdf
Manuscript File	1773-Review.doc
Answering Reviewers	1773-Answering reviewers.pdf
Copyright License Agreement	1773-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	ethical review board.pdf
Non-Native Speakers of English Editing Certificate	1773-Language certificate.pdf
Peer-review Report	1773-Peer reviews.pdf
Scientific Editor Work List	1773-Scientific editor work list.doc