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Publication Name World Journal of Gastroenterology
Manuscript ID 1773
Country/Territory Japan
Received
2013-01-05 12:08
Peer-Review Started
2013-01-05 14:35
To Make the First Decision
2013-03-04 13:57
Return for Revision
2013-04-02 15:00
Revised
2013-04-20 08:30
Second Decision
2013-05-16 20:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2013-05-17 09:56
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2013-06-28 10:39
Publish the Manuscript Online
2013-07-06 17:46
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology and Hepatology
Manuscript Type Autobiography
Article Title Differential mucin phenotypes and their significance in a variation of colorectal carcinoma
Manuscript Source Invited Manuscript
All Author List Yasuo Imai, Hidetsugu Yamagishi, Kazunori Fukuda, Yuko Ono, Tohru Inoue and Yoshihiko Ueda
Funding Agency and Grant Number
Funding Agency Grant Number
Haraguchi Memorial Trust Fund
Corresponding author Yasuo Imai, MD, Department of Pathology, Dokkyo Medical University Koshigaya Hospital, Minami-Koshigaya, Koshigaya, Saitama 343-8555, Japan. ya-imai@dokkyomed.ac.jp
Keywords Mucin 2; Mucin 5AC; Microsatellite instability; Mismatch repair; Colorectal carcinoma; Poorly differentiated adenocarcinoma; Pathogenesis; Adenoma-carcinoma sequence; Prognosis
Core Tip Altered mucin expression may be correlated with biological behavior and possibly with the prognosis of colorectal carcinoma (CRC). However, many contradictory results make it difficult to interpret its clinical significance, possibly because of CRC variations. Therefore, we examined mucin (MUC)2 and MUC5AC expressions in different pathological CRC subtypes by immunohistochemistry to determine their true clinical significance. Our results suggest that the expression profiles and the clinical significance of these mucin core proteins are different according to histological subtypes. This may reflect different pathogeneses for these tumors.
Publish Date 2013-07-06 17:46
Citation Imai Y, Yamagishi H, Fukuda K, Ono Y, Inoue T, Ueda Y. Differential mucin phenotypes and their significance in a variation of colorectal carcinoma. World J Gastroenterol 2013; 19(25): 3957-3968
Url http://www.wjgnet.com/1007-9327/full/v19/i25/3957.htm
DOI http://dx.doi.org/10.3748/wjg.v19.i25.3957
Full Article (PDF) WJG-19-3957.pdf
Manuscript File 1773-Review.doc
Answering Reviewers 1773-Answering reviewers.pdf
Copyright License Agreement 1773-Copyright assignment.pdf
Institutional Review Board Approval Form or Document ethical review board.pdf
Non-Native Speakers of English Editing Certificate 1773-Language certificate.pdf
Peer-review Report 1773-Peer reviews.pdf
Scientific Editor Work List 1773-Scientific editor work list.doc