Publication Name	World Journal of Gastroenterology
Manuscript ID	17730
Country	Italy

Received	2015-03-22 10:39
Peer-Review Started	2015-03-22 13:27
To Make the First Decision	2015-04-13 15:36
Return for Revision	2015-04-20 16:40
Revised	2015-04-28 22:42
Second Decision	2015-09-28 16:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-09-30 10:02
Articles in Press	2015-09-30 10:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-10-27 11:40
Publish the Manuscript Online	2015-11-11 13:34

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Role of matrix metalloproteinases in cholestasis and hepatic ischemia/reperfusion injury: A review
Manuscript Source	Invited Manuscript
All Author List	Giuseppina Palladini, Andrea Ferrigno, Plinio Richelmi, Stefano Perlini and Mariapia Vairetti
Funding Agency and Grant Number	Funding Agency Grant Number Fondazione Cariplo 2011-0439
Corresponding Author	Mariapia Vairetti, PhD, Department of Internal Medicine and Therapeutics, University of Pavia, Via Ferrata 9A, 27100 Pavia, Italy. mariapia.vairetti@unipv.it
Key Words	Matrix metalloproteinases; Liver; Ischemia/reperfusion; Cholestasis
Core Tip	Induction of matrix metalloproteinases (MMPs) modulates the progression of liver damage such as ischemia/reperfusion (I/R) injury and acute allograft rejection. The high incidence of biliary complications, after liver transplantation, is due to a cascade of events leading to biliary lesions to which cholangiocytes are particularly susceptible. This paper, while focusing on liver I/R and cholestasis, reviews factors and mechanisms implicated in MMP activation/regulation together with the role of MMPs in biliary complications following I/R injury. Recent data support the view that MMPs play a dual role, both good and bad, in liver I/R depending on the length of time after damage.
Publish Date	2015-11-11 13:34
Citation	Palladini G, Ferrigno A, Richelmi P, Perlini S, Vairetti M. Role of matrix metalloproteinases in cholestasis and hepatic ischemia/reperfusion injury: A review. World J Gastroenterol 2015; 21(42): 12114-12124
URL	http://www.wjgnet.com/1007-9327/full/v21/i42/12114.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i42.12114

Full Article (PDF)	WJG-21-12114.pdf
Full Article (Word)	WJG-21-12114.doc
Manuscript File	17730-Review.doc
Answering Reviewers	17730-Answering reviewers.pdf
Audio Core Tip	17730-Audio core tip.wma
Conflict-of-Interest Disclosure Form	17730-Conflict-of-interest statement.pdf
Copyright License Agreement	17730-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20150320231512.pdf
Peer-review Report	17730-Peer-review(s).pdf
Scientific Misconduct Check	17730-Scientific misconduct check.pdf
Scientific Editor Work List	17730-Scientific editor work list.pdf