Publication Name	World Journal of Hepatology
Manuscript ID	17740
Country	Italy

Received	2015-03-22 10:24
Peer-Review Started	2015-03-22 10:35
First Decision by Editorial Office Director
Return for Revision	2015-04-15 13:56
Revised	2015-05-01 01:22
Publication Fee Transferred
Second Decision by Editor	2015-05-15 16:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2015-05-28 18:22
Articles in Press	2015-05-28 18:22
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-06-06 16:13
Publish the Manuscript Online	2015-06-29 17:40

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Severe immune thrombocytopenia after peg-interferon-alpha2a, ribavirin and telaprevir treatment completion: a case report and systematic review of literature
Manuscript Source	Invited Manuscript
All Author List	Rosario Arena, Paolo Cecinato, Andrea Lisotti, Federica Buonfiglioli, Claudio Calvanese, Giuseppe Grande, Marco Montagnani, Francesco Azzaroli and Giuseppe Mazzella
Funding Agency and Grant Number
Corresponding Author	Dr. Andrea Lisotti, MD, Department of Medical and Surgical Sciences - DIMEC, University of Bologna, S.Orsola-Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy. lisotti.andrea@gmail.com
Key Words	Autoimmune thrombocytopenia; Pegylated interferon; Chronic hepatitis C; Viral hepatitis; Anti-platelet antibody
Core Tip	This is the second case report of autoimmune thrombocytopenia (AITP) occurred after peg-interferon/ribavirin treatment completion: generally, AITP was observed in course of interferon treatment. To our knowledge, among 24 interferon-related AITP cases reported in literature, in 23 cases the side effect occurred during treatment while in only one after treatment completion. Physicians using interferon-based antiviral therapy should be aware that acute AITP can occur both during and after treatment; in the case of suspected AITP, presence of anti-platelet antibodies should be checked not only during treatment but also after discontinuation.
Publish Date	2015-06-29 17:40
Citation	Arena R, Cecinato P, Lisotti A, Buonfiglioli F, Calvanese C, Grande G, Montagnani M, Azzaroli F, Mazzella G. Severe immune thrombocytopenia after peg-interferon-alpha2a, ribavirin and telaprevir treatment completion: A case report and systematic review of literature. World J Hepatol 2015; 7(12): 1718-1722
URL	http://www.wjgnet.com/1948-5182/full/v7/i12/1718.htm
DOI	http://dx.doi.org/10.4254/wjh.v7.i12.1718

Full Article (PDF)	WJH-7-1718.pdf
Full Article (Word)	WJH-7-1718.doc
Manuscript File	17740-Review.doc
Answering Reviewers	17740-Answering reviewers.pdf
Audio Core Tip	17740-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	17740-Conflict-of-interest statement.pdf
Copyright License Agreement	17740-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	17740-Institutional review board statement.pdf
Peer-review Report	17740-Peer-review(s).pdf
Scientific Misconduct Check	17740-Scientific misconduct check.pdf
Scientific Editor Work List	17740-Scientific editor work list.pdf